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An excellent 2017 review in this journal about d-amino acids by Genchi aims for a comprehensive representation of the current state of knowledge. Unfortunately, information about both d-proline and proline racemase is almost entirely missing. In our investigations into d/l-Pro-containing neuropeptides in cicadas, we have performed literature surveys in this context. Proline racemases in bacteria are known since 1957; their function has been studied mostly in prokaryotes and, more recently, proline racemase was identified in the unicellular eukaryotic parasite Trypanosoma cruzi. Published data on d-proline and/or proline racemase in other species are rare or non-existent.

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Luliberin analogues modified at the N-terminus were synthesized to search for drugs exerting a cytotoxic effect on cells of hormone-dependent tumors. A synthetic scheme effective in the preparation of analogues containing fatty acid residues was proposed. The cytotoxic effect of the peptides was studied on a number of cell lines of human tumors in vitro. The dependence of the antitumor effect on the length of peptide chain, amino acid sequence, and structure of the N-terminal group was demonstrated. Modification with palmitic acid was found to result in highly active compounds in the case of analogues containing more than ten aa, whereas modifications with lauric, caproic, or trimethylacetic acid led to compounds with significantly lower activities. Analogues of luliberin containing a palmitic acid residue and effectively inhibiting the growth of tumor cells in vitro were synthesized. Pleiades Publishing, Inc., 2006.

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

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Asymmetric total synthesis of (+)-epilupinine was achieved in just three steps using only commercially available common reagents. The total synthesis involved alkylations of N-nosylamide, ozone oxidation, and sequential reactions of the removal of the nosyl group, intramolecular dehydrative condensation, intramolecular Mannich reaction catalyzed by l-proline, and a reduction.

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Metal catalyst and ligand design,
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Cephalotaxine is the parent structure of an anticancer drug homoharringtonine (HHT). This review summarizes the strategic approaches toward the asymmetric total synthesis of (-)-cephalotaxine.

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

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A series of fluorinated analogs of the potent investigative anticonvulsant agent (4S,8aS)-4-phenylperhydropyrrolo[1,2-a]pyrazine-2,6-dione 1 was prepared and characterized by IR, 1H, 13C NMR and mass spectral data. The compounds have been evaluated in the in vivo rodent models of epilepsy. They displayed high activity in the ‘classical’ maximal electroshock seizure (MES) and subcutaneous Metrazol (scMET) tests as well as in the 6 Hz model of pharmacoresistant limbic seizures. The results showed that incorporating fluorine atoms into the phenyl ring of 1 can be beneficial for the anticonvulsant potency. The most promising meta-trifluoromethyl and meta-trifluoromethoxy derivatives (4S,8aS)-5h and (4S,8aS)-5l, respectively, displayed very broad spectra of activity across the preclinical seizure models.

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Metal catalyst and ligand design,
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The present invention relates to modulators of the calcium sensing receptor having the formula I (I) wherein Ar1, X, n, R1, R2, R3, and Q are as defined herein.

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Metal catalyst and ligand design,
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The synthesis of chiral functionalized beta-amino esters via the hydride reductive amination of chiral allenes was explored. These compounds can be regarded as beta-peptoids building blocks bearing a chiral side chain at the nitrogen and at the same time retaining the beta-amino acid side chain. beta-Enamino esters were obtained from the nucleophilic addition of alpha-amino esters (l-Ala, d-Ala, l-Phe, l-Leu, l-Trp and d-Trp methyl esters) to 2,3-allenoates bearing a chiral auxiliary, which determines the stereochemistry outcome of the subsequent reduction reaction. It was also demonstrated that in the reduction of beta-enamino esters derived from l-Pro and d-Pro methyl esters the chirality of the new chiral center is controlled by the alpha-amino ester moiety.

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

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Various embodiments of the present invention are directed to compounds of the formula (I) or a pharmaceutically ac­ceptable salt, polymorph, prodrug, solvate or clathrate thereof, wherein X1,X2, X3, R1, R2, R11, and n are defined herein. These com­pounds are useful as inhibitors of HIV-1 protease and, as a result, are useful in the treatment of HIV infection

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Metal catalyst and ligand design,
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In one aspect, the invention relates to compounds having the formula I: where R1-R6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising these compounds; methods of using these compounds; and processes and intermediates for preparing these compounds.

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Metal catalyst and ligand design,
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Compounds of (I), or stereoisomers or pharmaceutically acceptable salts thereof, where W, R1, R2, R3 and R4 have the meanings as indicated in the specification, are useful for treating conditions mediated by activation of the adenosine A2A receptor, especially inflammatory or obstructive airways diseases. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI