Category: 4392-87-4

Analyzing the synthesis route of 4392-87-4

As the paragraph descriping shows that 4392-87-4 is playing an increasingly important role.

4392-87-4,4392-87-4, [2,2′-Bipyridine]-6-carboxylic acid is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of H2bpdc, Fe(NO3)2¡¤9H2O and 10 mL H2O was put in a 15-mL Teflon-lined autoclave. After sonication, the mixture was kept under autogenous pressure at 160 C for 3 days and then cooled to room temperature at 10 C h-1.

As the paragraph descriping shows that 4392-87-4 is playing an increasingly important role.

Reference£º
Article; Xie, Jianhui; Zheng, Baocheng; Li, Bing; Transition Metal Chemistry; vol. 44; 5; (2019); p. 425 – 430;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Simple exploration of 4392-87-4

The synthetic route of 4392-87-4 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4392-87-4,[2,2′-Bipyridine]-6-carboxylic acid,as a common compound, the synthetic route is as follows.

(1) Preparation of (S)-6-(4-isopropyl-1-(p-tolyl)-4,5-dihydro-1H-imidazol-2-yl)-2,2′-bipyridine:2,2-bipyridyl-6-carboxylic acid (10 mmol)In thionyl chloride solution (5 mL)Reflow reaction for 8 h,The excess thionyl chloride was removed by rotary evaporation to give a pale yellow oil.Dissolve it in an anhydrous dichloromethane solution,In ice bath conditions,Adding and dissolving L-prolinol (11 mmol, 1.13 g) andTriethylamine (30mmol, 4.2 mL)In the anhydrous dichloromethane solution, after completion of the dropwise addition, the reaction was allowed to proceed at room temperature overnight.After completion of the reaction, the reaction was spun dry, ethyl acetate was added, and the insoluble material was removed by filtration.After the filtrate was spun dry, continue to add thionyl chloride (5 mL)Reacted under reflux for 8 h,The excess thionyl chloride was removed by rotary evaporation to give a reddish brown oil.Dissolve it in an anhydrous dichloromethane solution,In an ice bath, the solution was dissolved in p-toluidine (11 mmol, 1.2 g).And triethylamine (60 mmol, 8 mL)In anhydrous dichloromethane solution,After stirring at room temperature overnight,Add 10% aqueous sodium hydroxide solution (35 mL),Stirring was continued for 8-12 h at room temperature. After completion, the mixture was separated and the aqueous phase was extracted with dichloromethane three times.Drying with anhydrous magnesium sulfate, suction filtration, spin-drying and column chromatography (eluent ratio PE/EA = 3/1 to 1/10) gave the corresponding NNN’ ligand.Brown solid; yield: 50%;

The synthetic route of 4392-87-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Zhengzhou University; Hao Xinqi; Zhu Zhihui; Wang Yanbing; Wang Xiaodie; Wang Mengling; Zhao Xuemei; Zhu Xinju; Song Maoping; (8 pag.)CN109970814; (2019); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI