Category: 494-52-0

Computed Properties of C10H14N2. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (S)-3-(Piperidin-2-yl)pyridine, is researched, Molecular C10H14N2, CAS is 494-52-0, about Cell-membrane coated iron oxide nanoparticles for isolation and specific identification of drug leads from complex matrices. Author is Sherwood, Jennifer; Sowell, Josiah; Beyer, Nicholas; Irvin, Jessica; Stephen, Cayman; Antone, Angelo J.; Bao, Yuping; Ciesla, Lukasz M..

The lack of suitable tools for the identification of potential drug leads from complex matrixes is a bottleneck in drug discovery. Here, we report a novel method to screen complex matrixes for new drug leads targeting transmembrane receptors. Using α3β4 nicotinic receptors as a model system, we successfully demonstrated the ability of this new tool for the specific identification and effective extraction of binding compounds from complex mixtures The formation of cell-membrane coated nanoparticles was confirmed by transmission electron microscopy. In particular, we have developed a direct tool to evaluate the presence of functional α3β4 nicotinic receptors on the cell membrane. The specific ligand binding to α3β4 nicotinic receptors was examined through ligand fishing experiments and confirmed by high-performance liquid chromatog. coupled with diode-array detection and electrospray ionization mass spectrometry. This tool has a great potential to transform the drug discovery process focusing on identification of compounds targeting transmembrane proteins, as more than 50% of all modern pharmaceuticals use membrane proteins as prime targets.

This compound((S)-3-(Piperidin-2-yl)pyridine)Computed Properties of C10H14N2 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 494-52-0, is researched, SMILESS is C1(C=NC=CC=1)[C@@H]1CCCCN1, Molecular C10H14N2Journal, Article, Research Support, Non-U.S. Gov’t, Scientific Reports called Constitutive activation of nitrate reductase in tobacco alters flowering time and plant biomass, Author is Lu, Jianli; Chandrakanth, Niharika N.; Lewis, Ramsey S.; Andres, Karen; Bovet, Lucien; Goepfert, Simon; Dewey, Ralph E., the main research direction is tobacco nitrate reductase flowering biomass constitutive activation.Synthetic Route of C10H14N2.

Pyridine alkaloids produced in tobacco can react with nitrosating agents such as nitrite to form tobacco-specific nitrosamines (TSNA), which are among the most notable toxicants present in tobacco smoke. The market type known as burley tobacco is particularly susceptible to TSNA formation because its corresponding cultivars exhibit a nitrogen-use-deficiency phenotype which results in high accumulation of nitrate, which, in turn, is converted to nitrite by leaf surface microbes. We have previously shown that expression of a constitutively activated nitrate reductase (NR) enzyme dramatically decreases leaf nitrate levels in burley tobacco, resulting in substantial TSNA reductions without altering the alkaloid profile. Here, we show that plants expressing a constitutively active NR construct, designated 35S:S523D-NR, display an early-flowering phenotype that is also associated with a substantial reduction in plant biomass. We hypothesized that crossing 35S:S523D-NR tobaccos with burley cultivars that flower later than normal would help mitigate the undesirable early-flowering/reduced-biomass traits while maintaining the desirable low-nitrate/TSNA phenotype. To test this, 35S:S523D-NR plants were crossed with two late-flowering cultivars, NC 775 and NC 645WZ. In both cases, the plant biomass at harvest was restored to levels similar to those in the original cultivar used for transformation while the low-nitrate/TSNA trait was maintained. Interestingly, the mechanism by which yield was restored differed markedly between the two crosses. Biomass restoration in F1 hybrids using NC 645WZ as a parent was associated with delayed flowering, as originally hypothesized. Unexpectedly, however, crosses with NC 775 displayed enhanced biomass despite maintaining the early-flowering trait of the 35S:S523D-NR parent.

《Constitutive activation of nitrate reductase in tobacco alters flowering time and plant biomass》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound((S)-3-(Piperidin-2-yl)pyridine)Synthetic Route of C10H14N2.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (S)-3-(Piperidin-2-yl)pyridine, is researched, Molecular C10H14N2, CAS is 494-52-0, about Measuring dietary botanical diversity as a proxy for phytochemical exposure.Quality Control of (S)-3-(Piperidin-2-yl)pyridine.

The study of natural plant mols. and their medicinal properties, pharmacognosy, provides a taxonomy for botanical families that represent diverse chem. groupings with potentially distinct functions in relation to human health. Yet, this reservoir of knowledge has not been systematically applied to elucidating the role of patterns of plant food consumption on gut microbial ecol. and function. All chem. classes of dietary phytochems. can affect the composition of the microbes that colonize the gut and their function. In turn, the gut microbiome affects the host via multiple mechanisms including gut barrier function, immune function, satiety and taste regulation and the activity of biol. signaling pathways that influence health and disease. Herein, we report the development of a botanical diversity index (BDI) to evaluate plant food consumption as a novel metric for identifying and quantifying phytochems. to which an individual is exposed. A rationale is advanced for using the BDI to investigate how plant food diversity impacts gut microbial ecol. and functionality.

《Measuring dietary botanical diversity as a proxy for phytochemical exposure》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound((S)-3-(Piperidin-2-yl)pyridine)Quality Control of (S)-3-(Piperidin-2-yl)pyridine.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Supramolecular nano-encapsulation of anabasine reduced its developmental toxicity in zebrafish, published in 2020, which mentions a compound: 494-52-0, Name is (S)-3-(Piperidin-2-yl)pyridine, Molecular C10H14N2, Application In Synthesis of (S)-3-(Piperidin-2-yl)pyridine.

Anabasine (ANA), a major piperidine alkaloid originally isolated from wild tobacco trees (Nicotiana glauca), has been known to induce serious developmental toxicities such as skeletal deformities in livestock and humans. In this study, we thoroughly investigated the supramol. nano-encapsulations of ANA by an artificial nanocontainer, cucurbit[7] uril (CB[7]), and examined the influences of the nano-encapsulation on ANA’s inherent developmental toxicities on a zebrafish model. We have shown that CB[7] formed 1:1 host-guest inclusion complexes with ANA via a relatively high binding strength [Ka of (7.45 ± 0.31) x 104 M-1] in an aqueous solution, via UV-vis and 1 H NMR spectroscopic titrations, as well as isothermal titration calorimetry titration As a consequence, CB[7] significantly attenuated the developmental toxicity of ANA on zebrafish in vivo. In contrast, for a comparative purpose, β-CD didn’t exert any influence on the toxicity of ANA due to its weak binding with ANA, which was not even measurable via either spectroscopic methods or ITC titration This is the first head-to-head comparison of this pair of nanocontainers, CB[7] and β-CD, on their potential roles in influencing the toxicity of guest mols. and the results suggested that CB[7] could become a more promising functional excipient for reducing the inherent toxicities of active pharmaceutical ingredients, particularly alkaloids that may form relatively strong host-guest binding species with the host.

《Supramolecular nano-encapsulation of anabasine reduced its developmental toxicity in zebrafish》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound((S)-3-(Piperidin-2-yl)pyridine)Application In Synthesis of (S)-3-(Piperidin-2-yl)pyridine.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Hansen, Tina V. A.; Grencis, Richard K.; Issouf, Mohamed; Neveu, Cedric; Charvet, Claude L. published an article about the compound: (S)-3-(Piperidin-2-yl)pyridine( cas:494-52-0,SMILESS:C1(C=NC=CC=1)[C@@H]1CCCCN1 ).Related Products of 494-52-0. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:494-52-0) through the article.

The human whipworm, Trichuris trichiura, is estimated to infect 289.6 million people globally. Control of human trichuriasis is a particular challenge, as most anthelmintics have a limited single-dose efficacy, with the striking exception of the narrow-spectrum anthelmintic, oxantel. We recently identified a novel ACR-16-like subunit from the pig whipworm, T. suis which gave rise to a functional acetylcholine receptor (nAChR) preferentially activated by oxantel. However, there is no ion channel described in the mouse model parasite T. muris so far. Here, we have identified the ACR-16-like and ACR-19 subunits from T. muris, and performed the functional characterization of the receptors in Xenopus laevis oocytes using two-electrode voltage-clamp electrophysiol. We found that the ACR-16-like subunit from T. muris formed a homomeric receptor gated by acetylcholine whereas the ACR-19 failed to create a functional channel. The subsequent pharmacol. anal. of the Tmu-ACR-16-like receptor revealed that acetylcholine and oxantel were equally potent. The Tmu-ACR-16-like was more responsive to the toxic agonist epibatidine, but insensitive to pyrantel, in contrast to the Tsu-ACR-16-like receptor. These findings confirm that the ACR-16-like nAChR from Trichuris spp. is a preferential drug target for oxantel, and highlights the pharmacol. difference between Trichuris species.

Different reactions of this compound((S)-3-(Piperidin-2-yl)pyridine)Related Products of 494-52-0 require different conditions, so the reaction conditions are very important.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Feitoza, Rodrigo B. B.; Lima, Helena R. P. published an article about the compound: (S)-3-(Piperidin-2-yl)pyridine( cas:494-52-0,SMILESS:C1(C=NC=CC=1)[C@@H]1CCCCN1 ).Recommanded Product: (S)-3-(Piperidin-2-yl)pyridine. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:494-52-0) through the article.

The Papilionoideae, which comprises 503 genera and approx. 14,000 species, is the largest and most diverse subfamily of the Fabaceae family. In this subfamily, the Crotalarieae, Genisteae, Podalyrieae, Thermopsideae, Sophoreae and Euchresteae tribes are closely related by micro and macromol. features, thus forming the genistoid clade. This group combines well-known genera, whereas other genera lack phytochem. and chemotaxonomic studies. Thus, this work aimed to characterize the special metabolites in these genera in order to define the chem. profile, the micromol. markers and the chem. diversity, as well as to evaluate the group evolutionary trends. Flavonoids and alkaloids were identified as chemosystematic markers for the studied tribes due to high occurrence number and structural diversity. Among flavonoids, the flavones and isoflavones predominated. Low protection indexes of flavonoid hydroxyls by O-glycosylation or O-methylation were observed, whereas C-prenylation and C-glycosylation were frequent, mainly at C-6 and C-8 positions. The flavone/flavonol ratio shows the predominance of the flavones. Quinolizidine and piperidine alkaloids were present in most genera. Pyrrolizidine alkaloids were found in a few genera from Thermopsideae, Genisteae and Crotalarieae, which suggests a mechanism of adaptive convergence. Cluster anal. allowed separation of genera for each tribe by chem. similarities. The micromol. trends of protection of flavonoid hydroxyls and alkaloid oxidation indicate the genistoid clade is through evolutionary transition, which is consistent with its phylogenetic position in the Papilionoideae subfamily.

Different reactions of this compound((S)-3-(Piperidin-2-yl)pyridine)Recommanded Product: (S)-3-(Piperidin-2-yl)pyridine require different conditions, so the reaction conditions are very important.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Spleen is not required for therapeutic effects of 4OH-GTS-21, a selective α7 nAChR agonist, in the sub-acute phase of ischemic stroke in rats, published in 2021-01-15, which mentions a compound: 494-52-0, mainly applied to alpha nAChR agonist OHGTS therapeutic subacute ischemic stroke spleen; Alpha7; DMXBA; GTS-21; Ischemic stroke; Nicotinic; Spleen, Application In Synthesis of (S)-3-(Piperidin-2-yl)pyridine.

Acute ischemic stroke (AIS) causes both central and peripheral inflammation, while activation of α7 nicotinic acetylcholine receptors (nAChRs) provides both central and peripheral anti-inflammatory and anti-apoptotic effects. Here, we provide evidence that 4OH-GTS-21, a selective α7 agonist, produces its therapeutic effects via primarily central sites of action because 4OH-GTS-21 was found equally effective in splenectomized and non-spenectomized rats in the sub-acute phase of ischemic stroke (≤1 wk). However, the spleen may boost the therapeutic efficacy of 4OH-GTS-21 in certain behavioral tasks as our data also indicated. In our tests, AIS was modeled by transient middle cerebral artery occlusion (tMCAO). Splenectomy was done 2 wk before tMCAO. We determined that: (1) Daily 4OH-GTS-21 treatments for 7 days after tMCAO significantly reduced neurol. deficits and brain injury in both splenectomized and non-spelenectomized rats demonstrating that the spleen is not required for therapeutic benefits of 4OH-GTS-21; (2) The effects of 4OH-GTS-21 in the adhesive sticker removal test were significantly weaker in splenectomized animals suggesting that the spleen boosts the efficacy of 4OH-GTS-21 in the first week after tMCAO; and (3) Ischemic brain injury was not significantly affected by splenectomy in both vehicle-treated and 4OH-GTS-21-treated animals. These data support the hypothesis that the therapeutic efficacy of sub-chronic (≤1 wk) 4OH-GTS-21 primarily originates from central sites of action. These results validate brain availability as a critical factor for developing novel α7 ligands for AIS.

Different reactions of this compound((S)-3-(Piperidin-2-yl)pyridine)Application In Synthesis of (S)-3-(Piperidin-2-yl)pyridine require different conditions, so the reaction conditions are very important.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

HPLC of Formula: 494-52-0. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (S)-3-(Piperidin-2-yl)pyridine, is researched, Molecular C10H14N2, CAS is 494-52-0, about Agonist efficiency from concentration-response curves: Structural implications and applications.

Agonists are evaluated by a concentration-response curve (CRC), with a midpoint (EC50) that indicates potency, a high-concentration asymptote that indicates efficacy, and a low-concentration asymptote that indicates constitutive activity. A third agonist attribute, efficiency (η), is the fraction of binding energy that is applied to the conformational change that activates the receptor. We show that η can be calculated from EC50 and the asymptotes of a CRC derived from either single-channel or whole-cell responses. For 20 agonists of skeletal muscle nicotinic receptors, the distribution of η-values is bimodal with population means at 51% (including acetylcholine, nornicotine, and dimethylphenylpiperazinium) and 40% (including epibatidine, varenicline, and cytisine). The value of η is related inversely to the size of the agonist′s headgroup, with high- vs. low-efficiency ligands having an average volume of 70 vs. 102 Å3. Most binding site mutations have only a small effect on acetylcholine efficiency, except for αY190A (35%), αW149A (60%), and those at αG153 (42%). If η is known, the EC50 and high-concentration asymptote can be calculated from each other. Hence, an entire CRC can be estimated from the response to a single agonist concentration, and efficacy can be estimated from EC50 of a CRC that has been normalized to 1. Given η, the level of constitutive activity can be estimated from a single CRC.

Different reactions of this compound((S)-3-(Piperidin-2-yl)pyridine)HPLC of Formula: 494-52-0 require different conditions, so the reaction conditions are very important.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (S)-3-(Piperidin-2-yl)pyridine( cas:494-52-0 ) is researched.Computed Properties of C10H14N2.Deng, Yige; Ding, Songshuang; Zhu, Jiaming; Tian, Yuli; Qiao, Baoming; Shi, Xiangdong published the article 《Effect of drying density on change of main nitrogen compounds in drying process of cigar tobacco》 about this compound( cas:494-52-0 ) in Zhongguo Nongye Keji Daobao. Keywords: drying nitrogen compound cigar tobacco. Let’s learn more about this compound (cas:494-52-0).

In order to fully grasp the changes of nitrogen metabolites during the drying process of cigar tobacco leaves, to formulate a reasonable modulation process, the cigar tobacco variety ′Gu-5′ was used as material to study the effects of different air-drying densities (40, 60 and 80 pieces·rod-1) on the changes of the main nitrogen compounds in cigar tobacco leaves. The results showed that, under different air-drying densities, the changing trends of various nitrogen-containing compounds in tobacco leaves were basically consistent. Among them, the change of total nitrogen content showed a “”bimodal curve””, and the total nitrogen content was the lowest at the end of air-drying; soluble protein degradation mainly occurred during the wilting phase and the yellowing phase, and the accumulation of amino acids proceeded with protein degradation simultaneously, showing a “”fast-slow-fast”” variation trend; the total alkaloid content decreased slightly; nitrate did not change much between before and after air-drying. Among different air-drying densities, total nitrogen, protein and alkaloids of tobacco leaves were degraded the fastest under the treatment of 40 pieces·rod-1, and the three chem. components all reached the lowest value at 25 d after air-drying; amino acids content was fully accumulated during air-drying process and eventually reached 7.61 mg·g-1; its nitrate content was always the lowest during the whole air-drying process. Taken together, the drying d. of 40 pieces·rod-1 was more conducive to improving the quality and industrial availability of cigar tobacco leaves.

The article 《Effect of drying density on change of main nitrogen compounds in drying process of cigar tobacco》 also mentions many details about this compound(494-52-0)Computed Properties of C10H14N2, you can pay attention to it, because details determine success or failure

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Bondarenko, S. P.; Mrug, G. P.; Vinogradova, V. I.; Khilya, V. P.; Frasinyuk, M. S. researched the compound: (S)-3-(Piperidin-2-yl)pyridine( cas:494-52-0 ).Name: (S)-3-(Piperidin-2-yl)pyridine.They published the article 《Conjugation of the Alkaloid Anabasine to Coumarins》 about this compound( cas:494-52-0 ) in Chemistry of Natural Compounds. Keywords: anabasine formaldehyde aryl hydroxycoumarin regioselective Mannich aminomethylation; aryl hydroxycoumarinylmethyl anabasine preparation. We’ll tell you more about this compound (cas:494-52-0).

The possibility of using the alkaloid anabasine in Mannich aminomethylation of coumarins was studied. Anabasine-coumarin conjugates in which the benzopyrone core was conjugated to anabasine through a methylene linker were synthesized.

The article 《Conjugation of the Alkaloid Anabasine to Coumarins》 also mentions many details about this compound(494-52-0)Name: (S)-3-(Piperidin-2-yl)pyridine, you can pay attention to it, because details determine success or failure

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI