Category: 494-52-0

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Journal of Hazardous Materials called Efficiently capturing tobacco specific nitrosamines with Hβ zeolite in solution, Author is Shi, Chun Ling; Sun, Xiao Dan; Gao, Yi Han; Zheng, Sai Jing; Li, Shuo Hao; Yang, Jing; Wang, Yang Zhong; Xiong, Jun-Wei; Shen, Yi; Wang, Ying; Zhu, Jian Hua, which mentions a compound: 494-52-0, SMILESS is C1(C=NC=CC=1)[C@@H]1CCCCN1, Molecular C10H14N2, HPLC of Formula: 494-52-0.

The high-efficiency capture of Tobacco Specific Nitrosamines by Hβ zeolite in solution is reported for the 1st time, along with the adsorption of 4-methylnitrosamino-1-3-pyridyl-1-butanone in aqueous solution Different from other zeolites such as NaZSM-5, the specific pore size of Hβ exerted a crucial function endowing the zeolite a higher removal of TSNA and selectivity of NNK. The adsorption thermodn. of NNK by Hβ in aqueous adsorption was fitted to Temkin adsorption model with a linearly decreasing isosteric heat of adsorption. The adsorptive capacity of Hβ zeolite for NNK reached over 70 mg g-1, offering a powerful sorbent of TSNA to protect environment.

The article 《Efficiently capturing tobacco specific nitrosamines with Hβ zeolite in solution》 also mentions many details about this compound(494-52-0)HPLC of Formula: 494-52-0, you can pay attention to it or contacet with the author([email protected]; [email protected]) to get more information.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Related Products of 494-52-0. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (S)-3-(Piperidin-2-yl)pyridine, is researched, Molecular C10H14N2, CAS is 494-52-0, about Simultaneous determination of six alkaloids in tobacco and tobacco products by direct analysis of real-time triple quadrupole mass spectrometry with a modified pretreatment method. Author is Li, Chao; Li, E’xian; Ma, Ming; Liu, Xiuming; You, Junheng; Wu, Yiqin; Jiang, Wei; Liu, Zhihua; Qin, Yunhua.

In order to determine six alkaloids (mass fraction) of nicotine, nornicotine, myosmine, anatabine, anabasine, and nicotyrine in tobacco and tobacco products quickly, accurately, and simultaneously, a novel method based on direct anal. of real-time model in situ ionization technique combined tandem mass spectrometry with a modified sample pretreatment was established, in which exptl. parameters such as the type and amount of extraction solvent and injection rate were optimized, resp. The samples of five com. cigarettes and five kinds of tobacco leaves were analyzed by the established method, and the determined values were compared with those obtained using a gas chromatog. with mass spectrometry method: (1) Under optimized conditions (30 mL ultrapure water as extraction solvent and with extraction rate of 0.6 mm/s), anal. could be completed within 10 min. (2) The linear range of the method was 0.002-2000μg/g with R2=0.9957, the recovery ranged from 86.8 to 105.6%, and the limit of detection and the limit of quantification were 0.004-0.835μg/g and 0.013-2.787μg/g, resp. (3) The relative standard deviation between direct anal. of real-time method and the gas chromatog. with mass spectrometry method was 0.34-8.83%. The established method is rapid, reliable, and suitable for the ultrafast determination of six alkaloids in tobacco and tobacco products.

The article 《Simultaneous determination of six alkaloids in tobacco and tobacco products by direct analysis of real-time triple quadrupole mass spectrometry with a modified pretreatment method》 also mentions many details about this compound(494-52-0)Related Products of 494-52-0, you can pay attention to it, because details determine success or failure

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Nett, Ryan S.; Dho, Yaereen; Low, Yun-Yee; Sattely, Elizabeth S. published an article about the compound: (S)-3-(Piperidin-2-yl)pyridine( cas:494-52-0,SMILESS:C1(C=NC=CC=1)[C@@H]1CCCCN1 ).Category: catalyst-ligand. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:494-52-0) through the article.

Plants synthesize many diverse small mols. that affect function of the mammalian central nervous system, making them crucial sources of therapeutics for neurol. disorders. A notable portion of neuroactive phytochems. are lysine-derived alkaloids, but the mechanisms by which plants produce these compounds have remained largely unexplored. To better understand how plants synthesize these metabolites, we focused on biosynthesis of the Lycopodium alkaloids that are produced by club mosses, a clade of plants used traditionally as herbal medicines. Hundreds of Lycopodium alkaloids have been described, including huperzine A (HupA), an acetylcholine esterase inhibitor that has generated interest as a treatment for the symptoms of Alzheimers disease. Through combined metabolomic profiling and transcriptomics, we have identified a developmentally controlled set of biosynthetic genes, or potential regulon, for the Lycopodium alkaloids. The discovery of this putative regulon facilitated the biosynthetic reconstitution and functional characterization of six enzymes that act in the initiation and conclusion of HupA biosynthesis. This includes a type III polyketide synthase that catalyzes a crucial imine-polyketide condensation, as well as three Fe(II)/2-oxoglutarate-dependent dioxygenase (2OGD) enzymes that catalyze transformations (pyridone ring-forming desaturation, piperidine ring cleavage, and redox-neutral isomerization) within downstream HupA biosynthesis. Our results expand the diversity of known chem. transformations catalyzed by 2OGDs and provide mechanistic insight into the function of noncanonical type III PKS enzymes that generate plant alkaloid scaffolds. These data offer insight into the chem. logic of Lys-derived alkaloid biosynthesis and demonstrate the tightly coordinated coexpression of secondary metabolic genes for the biosynthesis of medicinal alkaloids.

The article 《A metabolic regulon reveals early and late acting enzymes in neuroactive Lycopodium alkaloid biosynthesis》 also mentions many details about this compound(494-52-0)Category: catalyst-ligand, you can pay attention to it or contacet with the author([email protected]) to get more information.

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Metal catalyst and ligand design,
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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Effects of plant alkaloids on mitochondrial bioenergetic parameters, published in 2021-08-31, which mentions a compound: 494-52-0, mainly applied to plant alkaloid mitochondrial bioenergetic parameter nicotinic acetylcholine receptor; Alkaloids; Mitochondria; Mitochondria permeability transition pore; Nicotinic acetylcholine receptors, Name: (S)-3-(Piperidin-2-yl)pyridine.

Mitochondria are among the first responders to various stress factors that challenge cell and tissue homeostasis. Various plant alkaloids have been investigated for their capacity to modulate mitochondrial activities. In this study, we used isolated mitochondria from mouse brain and liver tissues to assess nicotine, anatabine and anabasine, three alkaloids found in tobacco plant, for potential modulatory activity on mitochondrial bioenergetics parameters. All alkaloids decreased basal oxygen consumption of mouse brain mitochondria in a dose-dependent manner without any effect on the ADP-stimulated respiration. None of the alkaloids, at 1 nM or 1.25μM concentrations, influenced the maximal rate of swelling of brain mitochondria. In contrast to brain mitochondria, 1.25μM anatabine, anabasine and nicotine increased maximal rate of swelling of liver mitochondria suggesting a toxic effect. Only at 1 mM concentration, anatabine slowed down the maximal rate of Ca2+-induced swelling and increased the time needed to reach the maximal rate of swelling. The observed mitochondrial bioenergetic effects are probably mediated through a pathway independent of nicotinic acetylcholine receptors, as quant. proteomic anal. could not confirm their expression in pure mitochondrial fractions isolated from mouse brain tissue.

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: (S)-3-(Piperidin-2-yl)pyridine, is researched, Molecular C10H14N2, CAS is 494-52-0, about Genetics influence postharvest measurements of flue-cured tobacco more than nitrogen application rate, the main research direction is Nicotiana nitrogen nicotine alkaloids genotype plant genetics environment.Formula: C10H14N2.

Regulations under consideration by the U.S. Food and Drug Administration and the World Health Organization propose that nicotine concentration in tobacco (Nicotiana tabacum L.) should be lowered to non-addictive levels (0.3 to 0.5 mg g-1). The proposed standards are 90 to 95% lower than the nicotine concentration typically documented in com. available cultivars. Research was conducted in six environments to evaluate two cultivars with normal alkaloid levels (K326 and NC95) and four genotypes with low alkaloid levels (DH16A, DH22A, DH32, and LAFC53). Each cultivar and genotype was paired with three N application rates: 70, 85, and 100% of the recommended rate. As N application declined, so too did cured leaf yield and nicotine, anabasine, and anatabine concentration in K326 and NC95. These factors were generally not affected by N application in the low alkaloid genotypes. In contrast, LAFC53 consistently produced the lowest cured leaf quality, value, and reducing sugar concentration when compared to all other cultivars. This observation demonstrates that K326 isolines are agronomically superior to LAFC53. Despite reductions in nicotine, the lowest documented concentration was still 10-fold greater than the proposed min. (LAFC53). Nitrogen did not influence the measured parameters as much as genetics; therefore, addnl. research that involves other agronomic practices is warranted. In addition, further genetic manipulation will be required to meet the standards proposed by regulatory groups.

After consulting a lot of data, we found that this compound(494-52-0)Formula: C10H14N2 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Formula: C10H14N2. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (S)-3-(Piperidin-2-yl)pyridine, is researched, Molecular C10H14N2, CAS is 494-52-0, about Ethylene response factor NtERF91 positively regulates alkaloid accumulations in tobacco (Nicotiana tabacum L.).

Tobacco alkaloid metabolism is regulated by various transcription factors (TFs). Here, we have characterized a non-NIC2 locus gene, Ethylene Response Factor 91 (ERF91), function in regulation of alkaloid accumulation in tobacco. NtERF91 was preferentially expressed in roots and induced by jasmonic acid. Addnl., NtERF91 was able to in vitro bind to the NtPMT2 and NtQPT2 promoters via directly targeting the GCC-box elements and transactivate NtQPT2 gene expression. Ectopic overexpression of NtERF91 not only increased the expression of most nicotine biosynthetic genes, but also altered alkaloid accumulation profile, resulting in dramatically anatabine accumulation. We conclude that NtERF91 plays an overlapped but distinct role in regulating tobacco alkaloid accumulations.

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 494-52-0, is researched, SMILESS is C1(C=NC=CC=1)[C@@H]1CCCCN1, Molecular C10H14N2Journal, Article, Journal of Pharmaceutical and Biomedical Analysis called A simple dilute-and-shoot method for screening and simultaneous quantification of nicotine and alkaloid impurities in electronic cigarette refills (e-liquids) by UHPLC-DAD, Author is Barhdadi, Sophia; Desmedt, Bart; Courselle, Patricia; Rogiers, Vera; Vanhaecke, Tamara; Deconinck, Eric, the main research direction is nicotine alkaloid impurity quantification electronic cigarette liquid UHPLC DAD; Accuracy profiles; Impurities; Nicotine; UHPLC-DAD; e-cigarettes.Synthetic Route of C10H14N2.

The electronic cigarette (e-cigarette) has emerged as a popular alternative to the traditional hazardous tobacco cigarette. The substantial increase in e-cigarette use also urgently calls for controlling the quality of e-cigarette refill liquid products (e-liquids). Currently, the most important quality indicator of e-liquid products is the quantification of nicotine and its related impurities. Although different methods have been published to measure nicotine and impurity levels, the majority of them use a targeted LC-MS/MS approach. There is, however, a need for more robust quantification methods that are easy to implement in most control (industrial and governmental) laboratories Therefore, in this study, a simple dilute-and-shoot UHPLC-DAD method has been developed and validated for the simultaneous quantification of nicotine and its alkaloid impurities in electronic cigarette refills. An optimal separation of the alkaloids was achieved in a runtime of 11 min. The method was successfully validated using the “”total error”” approach in accordance with the validation requirements of ISO-17025. During this validation, interference between the target components and a number of popular flavouring compounds such as vanillin, maltol, ethylacetate, etc. could be excluded. In addition, small changes to the column temperature, pH and molar concentration of the mobile phase buffer were deliberately introduced to assess the robustness of the method. Only a slightly different outcome between the newly developed UV-detection method and the targeted MS approach was found, due to the sensitivity of the different detection techniques. However, in the context of quality control of nicotine related impurities, for which the European Pharmacopoeia limits are currently applied, the sensitivity of the UHPLC-DAD method was found to be within the acceptable range. Despite the somewhat lower selectivity of the newly developed UV-detection technique vs. a targeted LC-MS/MS approach, it may be concluded that this method is a suitable alternative for quality control purposes.

Although many compounds look similar to this compound(494-52-0)Synthetic Route of C10H14N2, numerous studies have shown that this compound(SMILES:C1(C=NC=CC=1)[C@@H]1CCCCN1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Alijevic, Omar; McHugh, Damian; Rufener, Lucien; Mazurov, Anatoly; Hoeng, Julia; Peitsch, Manuel published the article 《An electrophysiological characterization of naturally occurring tobacco alkaloids and their action on human α4β2 and α7 nicotinic acetylcholine receptors》. Keywords: Nicotiana solanaceae tobacco alkaloids nAChR nicotine anabasine anatabine; Anabasine; Anatabine; Nicotiana tabacum; Nicotine; Nornicotine; Solanaceae; Tobacco alkaloids; nAChR; α4β2; α7.They researched the compound: (S)-3-(Piperidin-2-yl)pyridine( cas:494-52-0 ).Reference of (S)-3-(Piperidin-2-yl)pyridine. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:494-52-0) here.

Nicotinic acetylcholine receptor (nAChR) subtype-selective pharmacol. profiles of tobacco alkaloids are essential for understanding the physiol. effects of tobacco products. In this study, automated electrophysiol. was used to functionally characterize the effects of distinct groups of tobacco alkaloids on human α4β2 and α7 nAChRs. We found that, in tobacco alkaloids, pyridine as a hydrogen bond acceptor and a basic nitrogen atom at a distance of 4-7 Å are pharmacophoric elements necessary for mol. recognition by α4β2 and α7 nAChRs with various degrees of selectivity, potency, and efficacy. While four alkaloids-nicotine, nornicotine, anabasine and R-anatabine-potently activated α4β2, they were also weak agonists of α7 nAChRs. Nicotine was the most potent agonist of α4β2, while anabasine elicited the highest activation of α7. None of the tobacco alkaloids enhanced nAChR activity elicited by the endogenous ligand acetylcholine; therefore, none was considered to be a pos. allosteric modulator (PAM) of either α4β2 or α7 nAChRs. In contrast, we identified tobacco alkaloids, such as the tryptophan metabolite 6-hydroxykynurenic acid, that decreased the activity of both α4β2 and α7 nAChRs. Our study identified a class of alkaloids with pos. and neg. effects against human α4β2 and α7 nAChRs. It also revealed human α4β2 to be the principal receptor for sensing the most abundant alkaloids in tobacco leaves.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Huang, X. H.; Song, J. J.; Li, H.; Gong, M. T.; Zhang, Y. researched the compound: (S)-3-(Piperidin-2-yl)pyridine( cas:494-52-0 ).COA of Formula: C10H14N2.They published the article 《Selective removal of nicotine from the main stream smoke by using a surface-imprinted polymer monolith as adsorbent》 about this compound( cas:494-52-0 ) in Journal of Hazardous Materials. Keywords: nicotine removal stream smoke surface imprinted polymer monolith adsorbent; Adsorption; Molecularly imprinted polymer; Nicotine; Selective removal; Surface-imprinted monolith. We’ll tell you more about this compound (cas:494-52-0).

Using molecularly imprinted polymer as a selective adsorbent for gaseous toxicants is a novel attempt. In present work, a nicotine surface-imprinted monolith (MIM) was used for the selective removal of nicotine from smoke. First, the retention capacity and selectivity for this MIM was tested by using it as the stationary phase in gas chromatog. and chromatog. conditions optimized. Then, the gas phase adsorption isotherms of MIM were constructed and the adsorption thermodn. explored. At last, the applicability for MIM in the removal of nicotine in smoke was explored. Results indicated a stronger retention capacity and a higher selectivity of MIM toward the template vapor, with a capacity factor (87.88) and a selectivity factor (10.15) under the optimized conditions. A higher standard adsorption enthalpy change for this MIM toward the template (|ΔH0a| = 65.53 kJ mol-1) than that for the non-imprinted monolith (NIM) column (|ΔH0a| = 47.46 kJ mol-1) was observed The adsorption isotherm for MIM appears the BET type II shape, while that for the NIM was approx. linear. When this MIM was used as the adsorbent, it exhibited a high performance in the selective removal of nicotine from the main stream smoke, with an adsorption percentage of 99.43%.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Application of 494-52-0. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: (S)-3-(Piperidin-2-yl)pyridine, is researched, Molecular C10H14N2, CAS is 494-52-0, about Effects of nicotinic acetylcholine receptor-activating alkaloids on anxiety-like behavior in zebrafish. Author is Alzualde, Ainhoa; Jaka, Oihane; Latino, Diogo A. R. S.; Alijevic, Omar; Iturria, Inaki; de Mendoza, Jorge Hurtado; Pospisil, Pavel; Frentzel, Stefan; Peitsch, Manuel C.; Hoeng, Julia; Koshibu, Kyoko.

Alkaloids are a structurally complex group of natural products that have a diverse range of biol. activities and significant therapeutic applications. In this study, we examined the acute, anxiolytic-like effects of nicotinic acetylcholine receptor (nAChR)-activating alkaloids with reported neuropharmacol. effects but whose effects on anxiety are less well understood. Because α4β2 nAChRs can regulate anxiety, we first demonstrated the functional activities of alkaloids on these receptors in vitro. Their effects on anxiety-like behavior in zebrafish were then examined using the zebrafish novel tank test (NTT). The NTT is a relatively high-throughput behavioral paradigm that takes advantage of the natural tendency of fish to dive down when stressed or anxious. We report for the first time that cotinine, anatabine, and methylanatabine may suppress this anxiety-driven zebrafish behavior after a single 20-min treatment. Effective concentrations of these alkaloids were well above the concentrations naturally found in plants and the concentrations needed to induce anxiolytic-like effect by nicotine. These alkaloids showed good receptor interactions at the α4β2 nAChR agonist site as demonstrated by in vitro binding and in silico docking model, although somewhat weaker than that for nicotine. Minimal or no significant effect of other compounds may have been due to low bioavailability of these compounds in the brain, which is supported by the in silico prediction of blood-brain barrier permeability. Taken together, our findings indicate that nicotine, although not riskfree, is the most potent anxiolytic-like alkaloid tested in this study, and other natural alkaloids may regulate anxiety as well.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI