Category: 5350-41-4

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5350-41-4,N,N,N-Trimethyl-1-phenylmethanaminium bromide,as a common compound, the synthetic route is as follows.

5350-41-4, General procedure: The desired amount of substrate, boronic acid (3 equiv), base (3equiv), Pd(OAc)2 (2.5 molpercent) and ligand (5 molpercent) were weighed out as solids, the vial was sealed and purged with argon, then solvent was added and the vial was purged again. The reactions were run for 14 h at the specified temperature. The crude material was filtered through a pad of Celite and washed three times with CHCl3. The solvent was removed under reduced pressure, an internal standard was added and the reaction was analysed by 1H NMR spectroscopy. For purification, the analysed mixture was concentrated, the product extracted with Et2O and filtered through anhydrous MgSO4 and further purified by flash column chromatography.

5350-41-4 N,N,N-Trimethyl-1-phenylmethanaminium bromide 21449, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Tuertscher, Paul L.; Davis, Holly J.; Phipps, Robert J.; Synthesis; vol. 50; 4; (2018); p. 793 – 803;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

5350-41-4, N,N,N-Trimethyl-1-phenylmethanaminium bromide is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The desired amount of substrate, boronic acid (3 equiv), base (3equiv), Pd(OAc)2 (2.5 molpercent) and ligand (5 molpercent) were weighed out as solids, the vial was sealed and purged with argon, then solvent was added and the vial was purged again. The reactions were run for 14 h at the specified temperature. The crude material was filtered through a pad of Celite and washed three times with CHCl3. The solvent was removed under reduced pressure, an internal standard was added and the reaction was analysed by 1H NMR spectroscopy. For purification, the analysed mixture was concentrated, the product extracted with Et2O and filtered through anhydrous MgSO4 and further purified by flash column chromatography., 5350-41-4

The synthetic route of 5350-41-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Tuertscher, Paul L.; Davis, Holly J.; Phipps, Robert J.; Synthesis; vol. 50; 4; (2018); p. 793 – 803;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

5350-41-4, N,N,N-Trimethyl-1-phenylmethanaminium bromide is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5350-41-4, General procedure: Ammonium salt 6 (1 equiv.) was suspended in dry THF (0.05 M) andstirred at 40 ¡ãC. t-BuOK (4 equiv.) was added and the mixture was stirred vigorously. After 10 minutes 2 equiv. of aldehyde 2 were added and the mixture was stirred for 3 hours at 40 ¡ãC. The reaction was then quenched by addition of a half-saturated NaCl solution. After phase separation, the aqueous phase was extracted three times with DCM and the combined organic phases were dried with Na2SO4 and evaporated to dryness. Purification by columnchromatography (gradient of heptanes and EtOAc) gave the corresponding epoxides in the reported yields as a mixture of diastereomers.

5350-41-4 N,N,N-Trimethyl-1-phenylmethanaminium bromide 21449, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Roiser, Lukas; Robiette, Raphael; Waser, Mario; Synlett; vol. 27; 13; (2016); p. 1963 – 1968;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5350-41-4,N,N,N-Trimethyl-1-phenylmethanaminium bromide,as a common compound, the synthetic route is as follows.

5350-41-4, [Method A (cations)] Titrationcurves were obtained in CDCl3 at 25 oC, by adding stocksolution of host 1 to a constantconcentration (2 mM) of a guest. Up-field shift of the guest cation, especiallyCH3 or CH2, was observed. Plots of the variations of thechemical shift of the guest upon addition of the titration were registered.[Method B (anions)] Similarly,titration curves were obtained in CDCl3 at 25 oC, byadding stock solution of a guest to a constant concentration (2 mM) of host 1. Since down-field shift of amideprotons of the host 1 was observed,plots of the variations of the chemical shift of the guest upon addition of thetitration were registered.[Estimation of Ka]Titration data were then treated according to a standard binding isotherm forthe case of 1:1 association.2 Non-linear curve fitting usingKaleidaGraph 4.1 (Synergy Software) software package afforded Ka and Ddmax.

5350-41-4 N,N,N-Trimethyl-1-phenylmethanaminium bromide 21449, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Akazome, Motohiro; Hamada, Norihiro; Takagi, Koji; Yagyu, Daisuke; Matsumoto, Shoji; Tetrahedron Letters; vol. 55; 14; (2014); p. 2226 – 2229;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

5350-41-4,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5350-41-4,N,N,N-Trimethyl-1-phenylmethanaminium bromide,as a common compound, the synthetic route is as follows.

General procedure: To a 50mL Schlenk tube containing benzylic ammonium iodide (0.5mmol), arylboronic acid (2.0mmol), K3PO4 (2.25mmol), castalyst (5molpercent) and PPh3 (20molpercent) were added and the tube was purged with N2 for 3 times. Then 1,4-dioxane (2.0mL), subsequently, was introduced to the tube. The resulted mixture was allowed to stir for 24h at 80¡ãC under atmosphere of N2. After the completion of the reaction, the resulting mixture was filtered through a Celite pad and concentrated under the vacuum and directly purified by flash chromatography to give the desired product.

As the paragraph descriping shows that 5350-41-4 is playing an increasingly important role.

Reference£º
Article; Liu, Xi-Yu; Zhu, Hai-Bo; Shen, Ya-Jing; Jiang, Jian; Tu, Tao; Chinese Chemical Letters; vol. 28; 2; (2017); p. 350 – 353;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI