Category: 54258-41-2

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.54258-41-2,1,10-Phenanthrolin-5-amine,as a common compound, the synthetic route is as follows.

54258-41-2, General procedure: Both compounds were synthesized in the same way. A mixture ofthe appropriate aldehyde [thiophene-2,5-dicarbaldehyde (283 mg,2.02 mmol), furan-2,5-dicarbaldehyde (316 mg, 2.55 mmol)] and5-amino-1,10-phenanthroline [(1091 mg, 5.59 mmol) withthiophene-2,5-dicarbaldehyde, (1458 mg, 7.48 mmol) with furan-2,5-dicarbaldehyde] was refluxed in EtOH (50 mL) containing acatalytic amount of acetic acid for 12 h, giving a suspension. Thereaction mixture was filtered hot, and the solid was washed withEtOH to afford the desired product as a yellow solid.N,N0-[thiophene-2,5-diylbis(methan-1-yl-1-ylidene)]bis(1,10-phenanthroline-5-amine): Yield 926 mg, 92.8%. 1H NMR (400 MHz,CDCl3): d = 7.44 (s, 2H), 7.65 (dd, J = 8.0, 4.4 Hz, 2H), 7.69 (s, 2H),7.72 (dd, J = 8.0, 4.4 Hz, 2H), 8.27 (dd, J = 8.4, 1.6 Hz, 2H), 8.87(dd, J = 8.0, 1.6 Hz, 2H), 8.90 (s, 2H), 9.17 (dd, J = 4.4, 1.6 Hz, 2H),9.26 (dd, J = 4.4, 2.0 Hz, 2H). ESI-MS: m/z = 495.3 [M+H]+. IR mmax(KBr, cm1): 3423 (br), 1590 s, 1563m, 1503w, 1485w, 1423m,1384 s, 1239m, 1204w, 1143w, 1110w, 1060m, 973w, 874w,802w, 743m, 627w, 523w, 414w.

54258-41-2 1,10-Phenanthrolin-5-amine 606970, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Cheng, Feixiang; He, Chixian; Yu, Shiwen; Yin, Hongju; Inorganica Chimica Acta; vol. 462; (2017); p. 43 – 49;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

54258-41-2,54258-41-2, 1,10-Phenanthrolin-5-amine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

YC-2 (0.5000 g, 1.236 mmol) and HATU (0.5091 g, 1.339 mmol) were dissolved in 7.5 mL of DMF, and TEA (0.1355 g, 1.339 mmol).Under a nitrogen atmosphere, after stirring at room temperature for 1-2 hours, 5-amino-1,10-phenanthroline was added.(0.2010 g, 1.030 mmol), warmed to 60 C, and allowed to react overnight.After the reaction was cooled to room temperature, the DMF was removed by spin-drying, the mixture was applied to silica gel, and the column was separated by chromatography (DCM:MeOH = 40:1).0.3235 g of a pale yellow solid was obtained with a yield of 54%.

54258-41-2 1,10-Phenanthrolin-5-amine 606970, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Suzhou University of Science and Technology; Sun Yanyan; (8 pag.)CN108558866; (2018); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.54258-41-2,1,10-Phenanthrolin-5-amine,as a common compound, the synthetic route is as follows.

General procedure: 4.2.1.4. Method D. A stirred solution of the 5-amino-1,10-phenanthroline (195 mg, 1 mmol), the monosaccharide (3 mmol) and ca. 4 mg of (NH4)2SO4 in 16 mL of MeOH was heated at 65 C for 24 or 48 h. During this time a pale yellow precipitate was accumulated. The reaction mixture was cooled and the solid obtained was separated by filtration and washed with MeOH (2 x 10 mL) and H2O (2 x 10 mL) to eliminate excess of sugar and possible traces of the starting amine and/or other by-products as well to remove the (NH4)2SO4 salt, followed by Et2O. This protocol provided pure N-(1,10-phenanthrolin-5-yl)-beta-glycopyranosyl amines 2a, 2c and 2d. For derivatives 2b and 2e the starting sugar could not be completely removed and a subsequent purification was required. The product was preadsorbed on silica gel and purified by flash chromatography. After drying in vacuum the purity of the products was checked by TLC, 1H NMR and analytical data. Derivatives 2a-e were obtained as monohydrates and exhibited poor solubility in water and organic solvents., 54258-41-2

54258-41-2 1,10-Phenanthrolin-5-amine 606970, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Duskova, Katerina; Gude, Lourdes; Arias-Perez, Maria-Selma; Tetrahedron; vol. 70; 5; (2014); p. 1071 – 1076;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

54258-41-2, 1,10-Phenanthrolin-5-amine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

54258-41-2, 5-Amino-1,10-phenanthroline (471 mg, 2.42 mmol) and 2,6-pyridinedicarbaldehyde (135 mg, 1 mmol) were refluxed in EtOH (20 mL) containing a catalytic amount of acetic acid for 6 h, giving a suspension. The reaction mixture was filtered hot, and the solid was washed with EtOH to afford the desired product as a yellow solid. Yield: 451 mg (92.2%). 1H NMR (300 MHz, CDCl3): delta = 7.48 (s, 2H), 7.65 (dd, J = 8.1, 4.5 Hz, 2H), 7.72 (dd, J = 8.4, 4.5 Hz, 2H), 8.14 (t, J = 7.5 Hz, 1H), 8.27 (d, J = 8.4 Hz, 2H), 8.57 (d, J = 7.5 Hz, 2H), 8.82 (d, J = 8.4 Hz, 2H), 8.96 (s, 2H), 9.17 (d, J = 3.9 Hz, 2H), 9.27 (d, J = 4.2 Hz, 2H). ESI-MS: m/z 490.4 (M+H)+, 512.4 (M+Na)+. IR numax (KBr, cm-1): 3399s (br), 1626s, 1593s, 1562m, 1501m, 1486m, 1453w, 1421s, 1385m, 1337w, 1298w, 1265w, 1209w, 1142w, 1061m, 993w, 977w, 941w, 866m, 799m, 738s, 679w, 626m, 526w, 458w, 412w.

54258-41-2 1,10-Phenanthrolin-5-amine 606970, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Cheng, Feixiang; Ren, Mingli; He, Chixian; Yin, Hongju; Inorganica Chimica Acta; vol. 450; (2016); p. 170 – 175;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

54258-41-2,54258-41-2, 1,10-Phenanthrolin-5-amine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Both compounds were synthesized in the same way. A mixture ofthe appropriate aldehyde [thiophene-2,5-dicarbaldehyde (283 mg,2.02 mmol), furan-2,5-dicarbaldehyde (316 mg, 2.55 mmol)] and5-amino-1,10-phenanthroline [(1091 mg, 5.59 mmol) withthiophene-2,5-dicarbaldehyde, (1458 mg, 7.48 mmol) with furan-2,5-dicarbaldehyde] was refluxed in EtOH (50 mL) containing acatalytic amount of acetic acid for 12 h, giving a suspension. Thereaction mixture was filtered hot, and the solid was washed withEtOH to afford the desired product as a yellow solid.

As the paragraph descriping shows that 54258-41-2 is playing an increasingly important role.

Reference£º
Article; Cheng, Feixiang; He, Chixian; Yu, Shiwen; Yin, Hongju; Inorganica Chimica Acta; vol. 462; (2017); p. 43 – 49;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI