Category: 6813-38-3

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6813-38-3,[2,2′-Bipyridine]-4,4′-dicarboxylic acid,as a common compound, the synthetic route is as follows.,6813-38-3

Thionyl chloride (300muL, 4.08mmol) was added to a suspension of 16 (400mg, 1.62mmol) in MeOH (30mL) in a dropwise fashion. The mixture was heated at reflux temperature overnight. Then, the solvent was removed under reduced pressure and the residue was partitioned between CH2Cl2 and water. The organic layer was washed with saturated aqueous NaHCO3 solution and dried over Na2SO4. Filtration, evaporation in vacuo, and recrystallization in AcOEt gave 17 (400mg, 91%): mp 200-202C; 1H NMR (CDCl3, 300MHz, delta; ppm), 8.92 (2H, d, J=4.2Hz), 8.85 (2H, s), 7.91 (2H, d, J=3.3Hz); 13C NMR (CDCl3, 75MHz, delta; ppm), 166.5, 156.0, 151.1, 140.0, 123.9, 120.0; MS (ESI) m/z 273.0 (MH+).

The synthetic route of 6813-38-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Miyake, Yuka; Itoh, Yukihiro; Hatanaka, Atsushi; Suzuma, Yoshinori; Suzuki, Miki; Kodama, Hidehiko; Arai, Yoshinobu; Suzuki, Takayoshi; Bioorganic and Medicinal Chemistry; vol. 27; 6; (2019); p. 1119 – 1129;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6813-38-3,[2,2′-Bipyridine]-4,4′-dicarboxylic acid,as a common compound, the synthetic route is as follows.,6813-38-3

Weigh 4,4′-dicarboxy-2,2′-bipyridine 500mg (2.05mmol) was added to the reaction flask, 100mL of methanol was added, 8mL of concentrated sulfuric acid was slowly added dropwise and stirred at 105 for 12h. After the reaction was completed and cooled to room temperature, the reaction was added to 500 mL of water, and the pH was adjusted to 9 using saturated NaOH solution. After the pH was adjusted, 200 mL of dichloromethane solution was added and allowed to stand still. At this time, a white flocculent precipitate was formed and the supernatant was poured out. The lower layer was extracted with dichloromethane and water (3 ¡Á 100 mL), the organic phase was extracted and dried to give the product , Yield 76%.

As the paragraph descriping shows that 6813-38-3 is playing an increasingly important role.

Reference£º
Patent; Nanjing University of Posts and Telecommunications; Zhang Yin; Zhang Taiwei; Sun Guanglan; Gao Pengli; Chen Xiaojiao; Zhao Qiang; Liu Shujuan; Huang Wei; (16 pag.)CN107417737; (2017); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

6813-38-3, [2,2′-Bipyridine]-4,4′-dicarboxylic acid is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6813-38-3, Take the product I obtained 2g and 10mL 98% H2SO4, 100mL CH3OH into the flask with a stirrer, reflux at 105 C overnight, the end of the reaction to a large amount of water appears white flocculent precipitate, slowly adding NaOH solution adjusted to pH 9.0 , With CH2C12 extract to retain the organic phase, anhydrous Na2S04 dry, evaporated to dry the solvent to obtain white crystals, the yield of 88%.

As the paragraph descriping shows that 6813-38-3 is playing an increasingly important role.

Reference£º
Patent; Nanjing University of Posts and Telecommunications; Zhao, Qiang; Huang, Wei; Huang, Tianci; Liu, Shujuan; Xu, Wenjuan; Zhu, Yana; (10 pag.)CN106188151; (2016); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

6813-38-3, [2,2′-Bipyridine]-4,4′-dicarboxylic acid is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6813-38-3, A monocarboxylic acid, 4-carboxy-4?-ethyl-2,2?-bipyridine 9 was identified as methyl ester as follows. Isolated mixture of 2 and 9 (Table 4, entry 5) was dissolved in 40 mL methanol, and 1 mL conc. H 2 SO 4 was added. The solution was refluxed for 24h, and then the cooled mixture was neutralized by adding aqueous NaHCO 3 solution. After removal of methanol at reduced pressure, H 2 O was added to the residue, and insoluble dimethyl 2,2′-bipyridine-4,4′-dicarboxylate S7 was filtered off and washed well with H 2 O. The filtrate and washings were combined and extracted with CH 2 Cl 2 . The organic layer was separated, dried with anhydrous Na 2 SO 4 , and the solvent was removed out under a reduced pressure. The colorless oil obtained was identified as 4-ethyl-4?-methoxycarbonyl-2,2?-bipyridine 16by its spectral data. The colorless oil solidified on standing several days in freezer. 4-Ethyl-4?-methoxycarbonyl-2,2?-bipyridine 16: mp 38-40C 1 H NMR (400 MHz, CDCl 3 ,TMS) ppm: 1.32 (3H, t, J=7.6 Hz), 2.76 (2H, q, J=7.6 Hz), 7.20 (1H, dd, J=5.0 Hz, 1.8 Hz), 7.86 (1H, dd, J=5.0 Hz, 1.8 Hz) 8.28 (1H, t, J=0.9 Hz), 8.61 (1H, d, J=5.0 Hz), 8.63 (2H, s), 8.82 (1H, dd, J=5.0 Hz, 0.9 Hz) 8.93 (1H, t, J=0.9 Hz); 13 C NMR (100 MHz, CDCl 3 , TMS) ppm: 14.4, 28.4, 52.7, 120.6, 120.9, 122.7, 123.9, 138.5, 149.3, 149.8, 154.2, 155.2, 157.5, 165.8. IR (ATR, cm -1 ) 3437, 3056, 2967, 2947, 2925, 2882, 2847, 1932, 1721, 1592, 1552, 1460, 1439, 1291, 1230, 1106, 963, 843, 747, 684; MS (EI) m/z(%) 242 (79) [M] + , 241 (96), 184 (100); Anal. Calcd for C 14 H 14 N 2 O 2 : C, 69.41; H, 5.82; N, 11.56. Found: C, 69.31; H, 6.00; N, 11.16.

The synthetic route of 6813-38-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Yamazaki, Shigekazu; Synthetic Communications; vol. 49; 17; (2019); p. 2210 – 2218;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI