Category: 7089-68-1

7089-68-1,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7089-68-1,2-Chloro-1,10-phenanthroline,as a common compound, the synthetic route is as follows.

Synthesis of 2-(1H-pyrazol-1-yl)-1,10-phenanthroline: 2-chloro-1,10-phenanthroline (2.13 g,10 mM), pyrazole (0.70 g, 10 mM), and potassium carbonate (1.50 g, 0.011 mM) weredissolved in 20mL of DMF. The mixture was refluxed for 24 h, then another batch ofpyrazole (0.34 g, 5.0 mM) and potassium carbonate (1.00 g, 7.2 mM) was added into theDMF solution and the reaction continued to reflux for another 48 h. After that, a fraction ofDMF was distilled out by vacuum and 40mL of ice water with crushed ice was added into the solution. The raw product then appeared and was separated by filtration. Then, theproduct was washed with ice water until the filtrate was neutral and the final product wasobtained by vacuum drying. 1H NMR (300MHz, CDCl3, 25 ¡ãC): delta = 9.19 (s, 2H), 8.40 (brs,2H), 8.28 (s, 1H), 7.82 (brs, 3H), 7.66 (s, 1H), 6.56 (s, 1H). HRMS (ESI): m/z calcd forC15H10N4+H+: 247.0978 [M+H+]; found: 247.0982. All other chemicals are analyticalgrade and used without purification.

As the paragraph descriping shows that 7089-68-1 is playing an increasingly important role.

Reference£º
Article; Li, Hong-Nan; Wei, Rui-Zheng; Chi, Yan-Hui; Wei, Wei; Du, Hua; Zhang, Shi-Guo; Shi, Jing-Min; Journal of Coordination Chemistry; vol. 66; 17; (2013); p. 3063 – 3071;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

7089-68-1, 2-Chloro-1,10-phenanthroline is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

7089-68-1, 2-(1H-Imidazol-1-yl)-1,10-phenanthroline was prepared according to the followingmethod. 2-Chloro-1,10-phenanthroline (4.29 g, 0.02 mol) and imidazole (1.63 g,0.024 mol) were dissolved with 100 mL of DMF and potassium carbonate (4.16 g, 0.030 mol) was added into the solution. After the reactants were refluxed for 72 h at110 ¡ãC, the solvent was removed by reduced pressure distillation. The pale yellow sediment appeared after 30 mL iced water was added into the remains and fully stirred.The pale yellow solid 2-(1H-imidazol-1-yl)-1,10-phenanthroline (4.5 g, yield: 91.8percent) was obtained after the sediment was washed with iced water until the pH value of the filtratewas 7. IR (cm-1): 3086 (w), 1593 (m), 1471 (vs), 1400 (m), 1295 (m), 1229 (m),1153 (m), 1049 (m), 973 (m), 820 (s), 765 (s), 726 (m), 648 (m); 1H NMR (300 MHz,CDCl3): 9.19?9.20 (m, 1H), 8.65 (s, 1H), 8.37?8.40 (d, 1H), 8.26?8.29 (d, 1H), 8.03 (s, 1H),7.73?7.81 (m, 5H); HRMS (ESI): C15H10N4 for MH, calculated 247.0984, found247.0985; Elemental Anal. Calcd for C15H10N4 (FW 246.0905): C, 73.20; H, 4.10; N,22.77percent. Found: C, 73.46; H, 4.25; N, 23.08percent.

7089-68-1 2-Chloro-1,10-phenanthroline 355193, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Zheng, Lu-Yi; Chi, Yan-Hui; Liang, Yuan; Cottrill, Ethan; Pan, Ning; Shi, Jing-Min; Journal of Coordination Chemistry; vol. 71; 23; (2018); p. 3947 – 3954;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI