Category: 7325-46-4

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7325-46-4,2,2′-(1,4-Phenylene)diacetic acid,as a common compound, the synthetic route is as follows.

Step 1: (0447) The reaction flask was charged with 2,2?-(1,4-phenylene)diacetic acid 30-a (9.2 g, 47.4 mmol) and ethanol (50 ml), concentrated sulfuric acid (5 ml, 94.8 mmol) was slowly added dropwise under stirring. The mixture was stirred at 80 C. overnight and then concentrated under reduced pressure to remove ethanol. Dichloromethane was added and the pH value of the aqueous layer was adjusted to 8 with saturated sodium bicarbonate solution. The aqueous phase was separated and extracted again with dichloromethane. The combined organic phase was dried and concentrated to give 30-b as solid (10.3 g, yield: 87%). ESI-MS (m/z): 251.2 [M+H]+.

As the paragraph descriping shows that 7325-46-4 is playing an increasingly important role.

Reference£º
Patent; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU VIGONVITA LIFE SCIENCES CO., LTD.; TOPHARMAN SHANDONG CO., LTD.; JIANG, Hualiang; WANG, Zhen; LI, Jianfeng; ZHANG, Rongxia; HE, Yang; LIU, Yongjian; BI, Minghao; LIU, Zheng; TIAN, Guanghui; CHEN, Weiming; YANG, Feipu; WU, Chunhui; WANG, Yu; JIANG, Xiangrui; YIN, Jingjing; WANG, Guan; SHEN, Jingshan; (70 pag.)US2017/158680; (2017); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

7325-46-4, 2,2′-(1,4-Phenylene)diacetic acid is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2,2′-(1,4-phenylene)diacetic acid (10.0 g, 51 mmol) was dissolved in ethanol (100 ml) and the solution treated dropwise with catalytic acetyl chloride (2.5 ml). The reaction mixture was stirred at reflux for 18 hours before being allowed to cool and concentrated in vacuo. The residue was taken up in ethyl acetate (100 ml) and extracted with sodium bicarbonate solution (3¡Á50 ml) and brine (3¡Á50 ml). The organic phase was then dried (magnesium sulphate) and concentrated in vacuo. The residue was triturated with pentane to yield the title product, 11.8 g. 1HNMR (CDCl3, 400 MHz) delta: 1.26 (t, 6H), 3.57 (s, 4H), 4.12 (q, 4H), 7.21 (m, 4H) MS (electrospray): m/z 273 [M+H]+

The synthetic route of 7325-46-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Brown, Alan Daniel; James, Kim; Lane, Charlotte Alice Louise; Moses, Ian Brian; Thomson, Nicholas Murray; US2005/171147; (2005); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI