Category: 7328-91-8

7328-91-8, 2,2-Dimethylpropane-1,3-diamine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of 2,2-dimethyl-1,3-propanediamine (5 mmol) in 10 mL absolute ethanol was added to a solution of 2-hydroxy-4-methoxybenzaldehyde (10mmol) in a three-necked round bottom flask. The resultant yellow solution was refluxed under nitrogen for 5 h. The ligand obtained as yellow microcrystals were filtered off, washed with cold ethanol and dried in a vacuum desiccator over blue silicagel [

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Reference£º
Article; Soh, Siti Kamilah Che; Shamsuddin, Mustaffa; Asian Journal of Chemistry; vol. 30; 1; (2018); p. 81 – 84;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

7328-91-8, 2,2-Dimethylpropane-1,3-diamine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General synthesis procedure: (for example, 3a) To a solution of ninhydrin (1 mmol) and malononitrile in EtOH (4 mL) was added triethylamine (0.1 mmol), and the solution was stirred for 1 h at room temperature. Then, nitro ketene dithioacetal 1 (1 mmol) and propyldiamine 2 (1 mmol) were added in sequence. Upon completion (11 h), monitored by TLC, the mixture was filtered and the precipitate washed with EtOH (4 mL) to afford the pure product 3a., 7328-91-8

Big data shows that 7328-91-8 is playing an increasingly important role.

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Article; Rezvanian, Atieh; Alizadeh, Abdolali; Tetrahedron; vol. 68; 49; (2012); p. 10164 – 10168,5;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

7328-91-8, 2,2-Dimethylpropane-1,3-diamine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2,2-dimethylpropane-1,3-diamine (5.0?g, Aldrich) was added to a solution of HCOOH (10 equiv) and HCHO (37% aqueous solution, 10?equiv), and was heated at reflux overnight, whereupon the solution was made basic by addition of NaOH (2?M, aqueous) and extracted into diethyl ether (4?*?25?mL). The ether solution was dried over K2CO3, and the solvent removed by rotary evaporation. The resulting oil was distilled in vacuo from CaH2 to afford the product as a colorless oil (75%). 1H NMR (CDCl3, 400?MHz): delta 0.9 (m, 6H); 2.0 (m, 4H); 2.2 (m, 12H). GC-MS: [60?C (1?min) to 180?C (2?min) at 30?C¡¤min-1]; tr?=?5.2?min (158, M+)., 7328-91-8

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Reference£º
Article; Large, Tao A.G.; Mahadevan, Viswanath; Keown, William; Stack, T. Daniel P.; Inorganica Chimica Acta; vol. 486; (2019); p. 782 – 792;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

7328-91-8, 2,2-Dimethylpropane-1,3-diamine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

N1-(5-chloro-4-(1-(phenylsulfonyl)-1H-indol-3-yl)pyrimidin-2-yl)-2,2-dimethylpropane-1,3-diamineA suspension of 3-(2,5-dichloropyrimidin-4-yl)-l-(phenylsulfonyl)-1H-indole (0.590g, 1.46mmol), 3,3-dimethylaminopropyldiamine (149mg, 1.46mmol) in EtOH/DMF (4: 1, lOmL) was heated at 130¡ãC (mW) for 20min. The mixture was diluted with EtOAc (30mL), washed with sat. NaHC03 (5mL), brine (5mL) dried (MgS04), filtered and concentrated under reduced pressure to afford the title compound (600mg, 1.28mmol, 87percent) as a white solid which was used in the next step without any further purification.

7328-91-8, The synthetic route of 7328-91-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SYROS PHARMACEUTICALS, INC.; PARAZA PHARMA, INC.; CIBLAT, Stephane; DEROY, Patrick; LEBLANC, Melissa; MARINEAU, Jason, J.; MOORE, Joel; ROY, Stephanie; SIDDIQUI, M., Arshad; SPROTT, Kevin; WINTER, Dana, K.; KABRO, Anzheliika; LEGER, Serge; MILLER, Tom; SCHMIDT, Darby; BRADLEY, Michael; WO2015/58163; (2015); A2;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

7328-91-8, 2,2-Dimethylpropane-1,3-diamine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Pyridine-2-carbaldehyde (30 mmol, 3.21 g)And 2,2-dimethyl-1,3-propanediamine (15 mmol, 1.53 g)30mL of methanol mixed,After 7.0 hours at room temperature,Slowly add NaBH4 (120 mmol, 4.54 g) slowly while stirring in an ice-water bath Slowly warmed to 70 for 5 hours.Stop the reaction,Cool to room temperature,Rotate the reaction solution.Then 50mL CH2Cl2 dissolved, filtered, Filtrate spin dry,Have yellow oily sticky substance.After dissolving the above yellow oily dope in 30 mL of methanol,To this was added an equimolar amount of aqueous formaldehyde solution,After stirring at room temperature for 3 hours,The solvent was removed under reduced pressure,Isolated and purified by column chromatography to give 3,3-dimethyl-1,3-bis (2-picolyl) hexahydropyrimidine (3.96 g, yield 89percent)., 7328-91-8

Big data shows that 7328-91-8 is playing an increasingly important role.

Reference£º
Patent; Henan University of Technology; Yang Liangru; Mai Wenpeng; Mao Pu; Xiao Yongmei; Yuan Jinwei; Qu Lingbo; (12 pag.)CN104744519; (2017); B;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI