Category: 787-70-2

787-70-2, [1,1′-Biphenyl]-4,4′-dicarboxylic acid is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,787-70-2

Step-1 : Synthesis of bis(2,5-dioxopyrrolidin-l-yl) biphenyl-4,4′-dicarboxylate (3399) [1182] To a stirred solution of biphenyl-4,4′-dicarboxylic acid (500 mg, 2.06 mmol) in 10 mL of DMF was added N-hydroxysuccinimide (594 mg, 5.16 mmol) and (3400) dicyclohexylcarbodiimide (1.06 g, 5.16 mmol) at 0C and the mixture stirred at RT overnight. The reaction mixture was filtered and the filtered cake was washed with EtOAc. The washings and filtrate were combined, washed with brine solution (3×20 mL), dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford a crude product that was dissolved in DCM and again filtered. The DCM layer was concentrated under reduced pressure to afford desired product (600 mg).

As the paragraph descriping shows that 787-70-2 is playing an increasingly important role.

Reference£º
Patent; MEDIVATION TECHNOLOGIES, INC.; HUNG, David; CHAKRAVARTY, Sarvajit; RAI, Roopa; BERNALES, Sebastian; SATHE, Balaji Dashrath; URETA, Gonzalo; MCCULLAGH, Emma; WO2015/116707; (2015); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.787-70-2,[1,1′-Biphenyl]-4,4′-dicarboxylic acid,as a common compound, the synthetic route is as follows.

Weigh 4,4′-biphthalic acid (10.00g, 41.3mmol) and silver sulfate (28.00g, 89.7mmol) into a 500mL double-necked flask, then add 250mL concentrated sulfuric acid and at room temperature Stir, then weigh the iodine element (23.00g, 90.5mmol) and add it to the double-necked flask, and cover the double-necked flask with tin foil for light-shielding treatment. The reaction takes place at room temperature for 1 hour, then the temperature is raised to 80 C, and the reaction is continued for 24 hours . After the reaction was completed, the reaction solution was cooled to room temperature, and the reaction solution in the double-necked flask was poured into 500 mL of ice water, resulting in a large amount of yellow precipitate, and the crude product was obtained by filtration. The above crude product was added to a 500 mL single-necked flask, and 300 mL of methanol was added. After stirring, 5 mL of concentrated sulfuric acid was slowly added dropwise, the temperature was raised to 100 C, the reaction was refluxed for 12 hours, cooled to room temperature, and the organic solvent was distilled off under reduced pressure. Saturated brine, and extracted three times with 500 mL of dichloromethane. The organic phase was dried over anhydrous magnesium sulfate, and the organic solvent was distilled off under reduced pressure. The organic solvent was purified by chromatography using methylene chloride as the eluent. 18.35 g of dimethyl ‘-diiodo-4,4’-diphthalate, that is, compound a, with a yield of 85.1% (based on dimethyl diphthalate)., 787-70-2

787-70-2 [1,1′-Biphenyl]-4,4′-dicarboxylic acid 13084, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Tongji University; Zhang Ronghua; Liu Changwei; Li Liangchun; (9 pag.)CN110483333; (2019); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.787-70-2,[1,1′-Biphenyl]-4,4′-dicarboxylic acid,as a common compound, the synthetic route is as follows.

787-70-2, Into a vessel was placed about 10 ml of dimethyl formamide (Fisher, 99%) which contained about 0.1 millimole of 4,4′ bipyridine under ambient atmospheric conditions. Into this, with stirring at ambient temperature (about 25 C.), was added about 0.3 millimoles of the zinc precursor polymer. Stirring was continued until the mixture was homogeneous, (about 10 minutes). The mixture was transferred in air to a Parr acid digestion bomb which was then sealed. The mixture was heated to 150 C. and held at that temperature for 3 days, yielding crystals of the zinc polymeric compound in about 94% yield based on the weight of the zinc precursor polymer compound. [0113] Synthesis of the Zinc Precursor Polymer [0114] The zinc precursor polymer compound used in the synthesis of the zinc polymeric compound of Example 3 was itself synthesized according to the following procedure. At room temperature (about 25 C.), into a vessel containing about 5.5 mL of a 0.01 molar bis-sodium biphenyl-4,4′-dicarboxylate aqueous solution (about 0.55 millimoles of the dicarboxylate, prepared as described below) was placed about 10 mL of a 0.1 molar aqueous Zn(NO3)2 solution (about 1.0 millimoles of zinc nitrate hexahydrate (Fisher) dissolved in 10 ml of deionized water). This immediately precipitated a mass of the zinc polymer precursor compound (stiochiometric formula [Zn(bpdc)(H2O)2].(H2O)], where ?bpdc? is biphenyl-4,4′-dicarboxylate). The precipitate was washed with distilled water and used as prepared. Yield was about 90% based on starting zinc nitrate. [0115] Bis-sodium-biphenyl-4,4′-dicarboxylate solution was prepared as described above in the preparation of the first cobalt precursor polymer, as described above in Example 1.

As the paragraph descriping shows that 787-70-2 is playing an increasingly important role.

Reference£º
Patent; Li, Jing; Pan, Long; Huang, Xiaoying; US2004/110950; (2004); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

787-70-2, [1,1′-Biphenyl]-4,4′-dicarboxylic acid is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,787-70-2

A mixture of H2BPDC (0.097g, 0.4mmol), Melamine (0.050g, 0.4mmol), DMF (4mL), ethanol (4mL) and H2O (4mL) was sealed into a 20mL Teflon-lined stainless-steel reactor and heated at 105C for 3days under autogenous pressure, and then followed by slowly cooling to room temperature at a rate of 1.7C¡¤h-1. The obtained flavescens cuboid-like crystals of 1 were collected (yield: 80 % based on Melamine) after washing with ethanol and drying in air. Elemental analysis: calcd. (%) for C20H30N12O8: C: 42.40, H: 5.34, N: 29.67, O: 22.59; found: C: 42.11, H: 5.81, N: 29.32, O: 22.76. FT-IR (KBr, 4000-500cm-1)=3380(w), 2667(w), 1890(m), 1686(vs), 1632(s), 1509(vs), 1390(m), 1205(m), 1009(w), 1004(m), 850(s), 760(s), 700(s) cm-1.

The synthetic route of 787-70-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Liu, Ruichao; Liu, Jie; Yan, Xiangzhen; Yuan, Chunxue; Polyhedron; vol. 157; (2019); p. 1 – 5;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

787-70-2,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.787-70-2,[1,1′-Biphenyl]-4,4′-dicarboxylic acid,as a common compound, the synthetic route is as follows.

A mixture of Co(OAc)2*4H2O (49.2 mg, 0.2 mmol), L1 (32.3 mg, 0.1 mmol), H2bpdc (48.4 mg, 0.2 mmol), NaOH (8.0 mg, 0.2 mmol), ethanol (4 mL) and water (10 mL) was heated at 140 C for 3 days in a 25 mL Teflon-lined vessel container. The mixture was then cooled to room temperature at a rate of 5 C/h. Purple crystals suitable for single-crystal X-ray diffraction were obtained by filtration and washed with distilled water in 58 % yield (based on Co(OAc)2*4H2O). Calcd. for C34H30CoN4O4 (Fw = 617.55): C 66.1, H 4.9, N 9.1 %. Found: C 65.9, H 5.1, N 9.3 %. IR (KBr, cm-1): 1605 s, 1560 m, 1510 m, 1430 m, 1300 m, 1178 w, 847 w, 758 m.

The synthetic route of 787-70-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Zhang, Xu; Liu, Yong Guang; Yu, Baoyi; Cui, Guang Hua; Transition Metal Chemistry; vol. 41; 2; (2016); p. 213 – 223;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.787-70-2,[1,1′-Biphenyl]-4,4′-dicarboxylic acid,as a common compound, the synthetic route is as follows.

A mixture of H2L (28.6mg, 0.1mmol), Cd(NO3)2¡¤4H2O (30.8mg, 0.1mmol), H2BPDA (24.2mg, 0.1mmol) and NaOH (8.0mg, 0.2mmol) in 10mL of H2O was sealed in a 16mL Teflon lined stainless steel container and heated at 180C for 3d. After the reaction mixture was cooled to room temperature, block crystals of 1 were collected with a yield of 32% by filtration and washed with water several times. Anal. Calc. for C32H22N4O4Cd: C, 60.15; H, 3.47; N, 8.77. Found: C, 60.52; H, 3.52; N, 8.85%. IR (KBr pellet, cm-1, Fig. S8): 1590 (s), 1573 (s), 1547 (s), 1543 (s), 1402 (m), 1126 (m), 1001 (m), 951 (s), 879 (m), 854 (w), 821 (m), 780 (m), 710 (w), 682 (w), 644 (w)., 787-70-2

As the paragraph descriping shows that 787-70-2 is playing an increasingly important role.

Reference£º
Article; Chen, Kai; Kang, Yan-Shang; Luo, Li; Zhao, Yue; Wang, Peng; Liu, Qing; Lu, Yi; Sun, Wei-Yin; Polyhedron; vol. 79; (2014); p. 239 – 249;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI