Category: 89972-77-0

Safety of 4-(p-Tolyl)-2,2:6,2-terpyridine. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 4-(p-Tolyl)-2,2:6,2-terpyridine, is researched, Molecular C22H17N3, CAS is 89972-77-0, about 4′-(4-Methylphenyl)-2,2′:6′,2”-terpyridine. Author is Liu, Han-Guo; Qiu, Yong-Cai; Wu, Jian-Zhong.

There are two crystallog. independent mols. in the asym. unit of the title compound, C22H17N3. In each mol., the three pyridyl groups are nearly coplanar, whereas the tolyl groups are twisted out of the plane of the attached pyridyl rings by ∼28°. The mol. components are assembled through C-H···π and π-π interactions [centroid-centroid distances are 3.677(4) and 3.707(7) Å] into a 1-dimensional chain running in the a-axis direction. Crystallog. data and at. coordinates are given.

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HPLC of Formula: 89972-77-0. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 4-(p-Tolyl)-2,2:6,2-terpyridine, is researched, Molecular C22H17N3, CAS is 89972-77-0, about Surmounting tumor resistance to metallodrugs by co-loading a metal complex and siRNA in nanoparticles. Author is Qiao, Hongzhi; Zhang, Lei; Fang, Dong; Zhu, Zhenzhu; He, Weijiang; Hu, Lihong; Di, Liuqing; Guo, Zijian; Wang, Xiaoyong.

Copper complexes are promising anticancer agents widely studied to overcome tumor resistance to metal-based anticancer drugs. Nevertheless, copper complexes per se encounter drug resistance from time to time. Adenosine-5′-triphosphate (ATP)-responsive nanoparticles containing a copper complex CTND and B-cell lymphoma 2 (Bcl-2) small interfering RNA (siRNA) were constructed to cope with the resistance of cancer cells to the complex. CTND and siRNA can be released from the nanoparticles in cancer cells upon reacting with intracellular ATP. The resistance of B16F10 melanoma cells to CTND was terminated by silencing the cellular Bcl-2 gene via RNA interference, and the therapeutic efficacy was significantly enhanced. The nanoparticles triggered a cellular autophagy that amplified the apoptotic signals, thus revealing a novel mechanism for antagonizing the resistance of copper complexes. In view of the extensive association of Bcl-2 protein with cancer resistance to chemotherapeutics, this strategy may be universally applicable for overcoming the ubiquitous drug resistance to metallodrugs.

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Farran, Rajaa; Le-Quang, Long; Mouesca, Jean-Marie; Maurel, Vincent; Jouvenot, Damien; Loiseau, Frederique; Deronzier, Alain; Chauvin, Jerome researched the compound: 4-(p-Tolyl)-2,2:6,2-terpyridine( cas:89972-77-0 ).Application of 89972-77-0.They published the article 《[Cr(ttpy)2]3+ as a multi-electron reservoir for photoinduced charge accumulation》 about this compound( cas:89972-77-0 ) in Dalton Transactions. Keywords: chromium ruthenium polypyridyl photoinduced electron transfer. We’ll tell you more about this compound (cas:89972-77-0).

[Cr(ttpy)2]3+ (ttpy = 4′-(4-methylphenyl)-2,2′:6,2′′-terpyridine) exhibits rich electrochem. and photophys. properties. Cyclic voltammetry performed in CH3CN shows in the cathodic part the presence of three one-electron reversible systems at -0.47, -0.85 and -1.35 V vs. Ag/AgNO3 10-2 M. These systems are attributed to the reduction of the terpyridine ligands with a partial delocalization of the charge on the tolyl for the last reduction event. The three different reduced species were generated by exhaustive electrolysis and characterized by EPR and UV-visible spectroscopy; DFT calculations were performed to locate the spin d. of the electrons added during the reduction Visible light irradiation of [Cr(ttpy)2]3+ induces the population of a luminescent metal-centered excited state with a lifetime of 270 ns in deoxygenated CH3CN. This excited state can be quenched by an electron transfer process with triphenylphosphine (PPh3) or triethanolamine (TEOA). Using TEOA as a sacrificial electron donor, the doubly reduced species (i.e.[Cr(ttpy)2] +) can be generated under continuous irradiation In the presence of [Ru(bpy)3]2+ as an addnl. photosensitizer, the photoreduction of [Cr(ttpy)2]3+ towards [Cr(ttpy)2]+ is accelerated. The trinuclear [{RuII(bpy)2(bpy-O-tpy)}2CrIII]7+ complex ([Ru2Cr]7+) in which a CrIII-bis-terpyridine center is covalently linked to two RuII-tris-bipyridine moieties by oxo bridges has been synthesized. Its electrochem., photophys. and photochem. properties were investigated in deoxygenated CH3CN. Cyclic voltammetry indicates only a poor electronic communication between the different subunits, whereas luminescence experiments show a strong quenching of the RuII* excited state by an intramol. process. Continuous irradiation of [Ru2Cr]7+ under visible conditions in the presence of TEOA leads to [Ru2Cr]4+ where three electrons are stored on the [Cr(ttpy)] subunit.

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SDS of cas: 89972-77-0. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 4-(p-Tolyl)-2,2:6,2-terpyridine, is researched, Molecular C22H17N3, CAS is 89972-77-0, about Synthesis, crystal structure and thermal properties of Cd(II) and Hg(II) terpyridine based compounds. Author is Saghatforoush, Lotfali; Pourmohsen, Mehrdad; Asgari, Parvin.

Cd(II) and Hg(II) compounds of 4′-(4-methylphenyl)-2,2′:6′,2”-terpyridine (Mephtpy), [Cd(Mephtpy)I2] and [Hg(Mephtpy)I2], were synthesized and characterized by CHN elemental anal., FTIR, 1H and 13C NMR, thermal anal. and analyzed structurally by x-ray single-crystal diffraction. X-ray anal. showed that the coordination number in the complexes were the same with an N3I2 coordination sphere. Both metal ions adopt a distorted square-pyramidal geometry. The thermogravimetric analyses showed that the complexes were stable up to 365 and 340°, resp.

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Product Details of 89972-77-0. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 4-(p-Tolyl)-2,2:6,2-terpyridine, is researched, Molecular C22H17N3, CAS is 89972-77-0, about Zn(II) complex of terpyridine for the highly selective fluorescent recognition of pyrophosphate. Author is Liang, Li Jiao; Zhao, Xi Juan; Huang, Cheng Zhi.

Pyrophosphate ion (PPi) is crucial in varieties of biol. processes and industrial applications, and thus it is very important how to recognize it with high selectivity. In this contribution, one terpyridine (tpy)-based fluorescent mol., 4-(methylphenyl)-2,2′:6′,2”-terpyridine (mptpy), was reported to display a highly selective recognition for PPi in the presence of Zn(II). After exposure toward the Zn(II) ion, the characteristic emission of mptpy at 376 nm red shifted to 406 nm with a strong enhancement upon an excitation at 280 nm, and then blue-shifted to 388 nm with the further addition of PPi. After exposure toward the Zn(II) ion, the characteristic emission of mptpy at 376 nm red shifted to 406 nm with a strong enhancement upon an excitation at 280 nm, and then blue-shifted to 388 nm with the further addition of PPi. This process could also discriminate PPi from other inorganic anions. Therefore, a tpy-based fluorescence method for the highly selective recognition of PPi could be developed.

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 4-(p-Tolyl)-2,2:6,2-terpyridine( cas:89972-77-0 ) is researched.Application In Synthesis of 4-(p-Tolyl)-2,2:6,2-terpyridine.Wang, Xiao-xia; Liu, Han-guo; Wan, Xia; Yin, Xia; Zhou, Fu-shan; Wu, Jian-zhong published the article 《Synthesis of 4-tolyl-2,2′:6′,2”-terpyridine》 about this compound( cas:89972-77-0 ) in Huaxue Shiji. Keywords: methylphenyl terpyridine preparation cyclization. Let’s learn more about this compound (cas:89972-77-0).

3-(4-Methylphenyl)-1,5-di(2-pyridinyl)-1,5-pentanedione was prepared by reaction of 2-acetylpyridine with 4-methylbenzaldehyde at room temperature using ethanol as the solvent. Treatment of the latter compound with concentrated ammonia for 1 h in the presence of sodium hydroxide gave the title compound [i.e., 4′-(4-methylphenyl)-2,2′:6′,2”-terpyridine] in 31.7% yield. The above reaction conditions were mild and the products could be purified easily.

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 4-(p-Tolyl)-2,2:6,2-terpyridine(SMILESS: CC1=CC=C(C2=CC(C3=NC=CC=C3)=NC(C4=NC=CC=C4)=C2)C=C1,cas:89972-77-0) is researched.Name: Copper(I) tetra(acetonitrile) tetrafluoroborate. The article 《Furin Inhibition by Compounds of Copper and Zinc》 in relation to this compound, is published in Journal of Biological Chemistry. Let’s take a look at the latest research on this compound (cas:89972-77-0).

Furin, a human subtilisin-related proprotein convertase (SPC), is emerging as an important pharmaceutical target because it processes vital proteins of many aggressive pathogens. Furin inhibitors reported as yet are peptide derivatives and proteins, with the exception of andrographolides, which are natural compounds Here we report that the small and highly stable compounds M(chelate)Cl2 (M is copper or zinc) inhibit furin and Kex2, with Cu(TTP)Cl2 and Zn(TTP)Cl2 as the most efficient inhibitors. 4′-[P-tolyl]-2,2′:6′,2”-terpyridine (TTP) inhibitor is irreversible, competitive with substrate, and affected by substituents on the chelate. The free chelates are not inhibitors. Solvated Zn2+ is less potent than its complexes. This is true also for copper and Kex2. However, solvated Cu2+ (kon of 25,000±2,500 s-1) is more potent than Cu(TTP)Cl2 (kon = 140±13 s-1) and allows recovery of furin activity prior to a second inhibition phase. A mechanism that involves coordination to the catalytic histidine is proposed for all inhibitors. Target specificity is indicated by the fact that these metal chelate inhibitors are much less potent toward Kex2, the yeast homolog of furin. For example, kon with Zn(TTP)Cl2 is 120±20 s-1 for furin, but only 1.2±0.1 s-1 for Kex2.

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Vaduvescu, Simona; Potvin, Pierre G. published an article about the compound: 4-(p-Tolyl)-2,2:6,2-terpyridine( cas:89972-77-0,SMILESS:CC1=CC=C(C2=CC(C3=NC=CC=C3)=NC(C4=NC=CC=C4)=C2)C=C1 ).Reference of 4-(p-Tolyl)-2,2:6,2-terpyridine. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:89972-77-0) through the article.

Four ditopic bridging ligands, containing 2,2′:6′,2”-terpyridine and 2,6-dipyrazinylpyridine (dpp) metal-binding units attached through p- or m-phenylene linkages, were incorporated into eight mono-, di- and trinuclear linear Ru(II) complexes. These were characterized by UV/visible spectroscopy and cyclic voltammetry, and by their ability to undergo light-induced electron transfers to methylviologen. The dpp-bearing complexes were more difficult to prepare but were superior sensitizers, a fact attributable to longer excited state lifetimes and an electrostatically favored reductive quenching pathway.

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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 4-(p-Tolyl)-2,2:6,2-terpyridine, is researched, Molecular C22H17N3, CAS is 89972-77-0, about Synthesis, crystal structure and electrochemical behavior of two new Ni-based complexes: [Ni2(ttpy)2(SCN)4] and [Ni(ttpy)2](CH3OH)2(2I), the main research direction is nickel tolylterpyridine complex preparation crystal structure cyclic voltammetry.Computed Properties of C22H17N3.

A simple synthetic procedure was used to prepare two new nickel(II) complexes [Ni2(ttpy)2(SCN)4], (1) and [Ni(ttpy)2](CH3OH)2(2I), (2) from 4′-p-tolyl-2,2′:6′,2”-terpyridine (ttpy) ligand, potassium thiocyanate, and potassium iodide in good yields. The single crystal x-ray analyses reveal that the metals in these complexes are sixfold coordinated with M:L ratio of 1:1 and 1:2 for (1) and (2), resp. In both complexes, the Ni(II) has distorted octahedral geometry including N5S and N6 environments. Versatile interactions in supramol. level containing coordinative bonding, I···H, and N···H hydrogen bonding, π-π stacking play considerable roles in forming crystal packing of (1) and (2). From obtained data differences in coordination abilities, of used counterions, cause the formation of complexes with 1:1 or 1:2 ratio of metal and ligand. Electrochem. behaviors of the both complexes were studied.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 89972-77-0, is researched, SMILESS is CC1=CC=C(C2=CC(C3=NC=CC=C3)=NC(C4=NC=CC=C4)=C2)C=C1, Molecular C22H17N3Journal, Yingxiang Kexue Yu Guang Huaxue called Investigation on mixed-valence charge transfer state of cobalt(II)-bis[4′-ferrocenyl-2,2′: 6′,2”-terpyridyl] complex, Author is Liu, Xian-yu; Wang, Jiu-ju; Li, Zhi-jun; Zhang, Li-ping; Tong, Zhen-he; Wu, Li-zhu, the main research direction is mixed valence charge transfer cobalt ferrocenyl terpyridyl complex.Name: 4-(p-Tolyl)-2,2:6,2-terpyridine.

Cobalt(II)-bis[4′-ferrocenyl-2,2′: 6′,2”-terpyridyl] complex 1 and reference complexes cobalt(II)-bis[4′-(4-methylphenyl)-2,2′: 6′,2”-terpyridyl] (2) and cobalt(II)-bis[2,2′: 6′,2”-terpyridyl] (3) were designed and synthesized. Complex 1 exhibits obvious low-energy absorption from 500 to 700 nm due to introduction of electro-donating ferrocenyl group, which could be switched to mixed-valence charge transfer state ranged from 500 to 800 nm upon partial oxidation

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