Category: 92149-07-0

Chemistry is traditionally divided into organic and inorganic chemistry. category: catalyst-ligand. The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 92149-07-0

This invention provides novel compounds that are modulators of gamma secretase. The compounds have the formula (I). Also disclosed are methods of modulating gamma secretase activity and methods of treating Alzheimer’s disease using the compounds of formula (I).

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Reference：
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent， name: 4,7-Dimethoxy-1,10-phenanthroline, Which mentioned a new discovery about 92149-07-0

In this work, the compounds fac-[ReL(CO)3(NN)]0/+1, NN = 1,10-phenanthroline, phen, 4,7-dimethyl-1,10-phenanthroline, Me2phen, or 4,7-dimethoxy-1,10-phenanthroline, (MeO)2phen, and L = Cl? or triphenylphosphine, PPh3, were synthetized and characterized by 1H NMR, UV?vis and FTIR spectroscopies and their photophysical properties were investigated by steady-state and time-resolved emission spectroscopies. All complexes displayed strong absorption in the high energy UV-region assigned to intraligand transitions, ILNN, and the lower energy band was ascribed to a metal-to-ligand charge transfer, MLCTRe?NN. The two electron donor groups attached to phen ligand shifted the emission maxima of the complexes to higher energy as the substituent becomes more electron donor, consequently the contribution of the 3ILNN on the 3MLCT emission becomes more evident. This effect is enhanced by coordinating the electron-withdrawing PPh3 ligand on Re(I) complexes (lambdamax = 515 nm, ? = 13%, tau = 2.52 mus for phen; lambdamax = 512 nm, ? = 8.2%, tau = 2.00 mus for Me2phen; lambdamax = 478 and 506 nm, ? = 1.1%, tau = 1.12 mus for (MeO)2phen). This interference is supported by the small shift of the emission maxima and two lifetimes in the mus domain observed for substituted-phen complexes in PMMA films. The photophysics of Re(I) compounds reported herein provides new insights into the understanding of electron-donor groups on the phen ligand that are relevant to practical and fundamental development of photoinduced molecular devices.

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Reference：
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Electric Literature of 92149-07-0, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 92149-07-0, Name is 4,7-Dimethoxy-1,10-phenanthroline, molecular formula is C14H12N2O2. In a Patent，once mentioned of 92149-07-0

This invention provides novel compounds that are modulators of gamma secretase. The compounds have the formula (I). Also disclosed are methods of modulating gamma secretase activity and methods of treating Alzheimer’s Disease using the compounds of formula (I)

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Electric Literature of 92149-07-0, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 92149-07-0, in my other articles.

Reference：
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Recommanded Product: 92149-07-0, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 92149-07-0, Name is 4,7-Dimethoxy-1,10-phenanthroline, molecular formula is C14H12N2O2. In a Article, authors is Altman, Ryan A.，once mentioned of 92149-07-0

(Chemical Equation Presented) The use of 3,4,7,8-tetramethyl-1,10- phenanthroline (Me4Phen) as a ligand improves the Cu-catalyzed cross-coupling reactions of aryl iodides and bromides with primary and secondary aliphatic, benzylic, allylic, and propargylic alcohols. Most importantly, by employing this catalyst system, the need to use an excessive quantity of the alcohol coupling partner is alleviated. The relatively mild conditions, short reaction times, and moderately low catalyst loading allow for a wide array of functional groups to be tolerated on both the electrophilic and nucleophilic coupling partners.

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent£¬ HPLC of Formula: C14H12N2O2, Which mentioned a new discovery about 92149-07-0

Copper-Catalyzed Coupling Reactions of Aryl Halides and Phenols by 4,4?-Dimethoxy-2,2?-bipyridine and 4,7-Dimethoxy-1,10-phenanthroline

Several Cu(I) complexes of 2,2?-bipyridines were studied for the catalytic coupling of aryl iodides and phenols and 4,4?-dimethoxy-2,2?-bipyridine was shown to be an effective ligand of CuI in 1:2 (CuI:ligand) ratio for the synthesis of a wide range of diaryl ethers (up to 97% yield) using K3PO4 as base in DMF at 100 C. The catalysis was highly dependent on the reaction temperature and was successfully applied in the coupling with more attractive and challenging substrates, aryl bromides, at 140 C in good-to-excellent yields (78?95%). Moreover, the heteroaromatic effect for the reaction was studied and gave a comparable result with phenyl group (up to 95% yield). Significantly, a structurally related N,N-bidentate ligand, 4,7-dimethoxy-1,10-phenanthroline, exhibited better performance for less-reactive combinations of aryl halides and phenols.

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Reference£º
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Chemistry is traditionally divided into organic and inorganic chemistry. Computed Properties of C14H12N2O2. The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 92149-07-0

Mechanistic Insights into the Stepwise Assembly of Ruthenium(II) Tris-heteroleptic Compounds

The ruthenium(II) tris-heteroleptic compounds cis-[Ru(NN)(dcbH2)(NCS)2], NN = polypyridyl ligand and dcbH2 = 2,2?-bipyridine-4,4?-dicarboxylic acid, can be synthesized by a one-pot route starting from [Ru(p-cymene)Cl2]2, followed by the sequential addition of ligands. In this work, each synthetic step for the cis-[Ru(R-phen)(dcbH2)(NCS)2] (R = H, Me, Ph, MeO, or Cl) preparation was individually investigated, aiming to identify reaction intermediates and to establish correlations among temperature, reaction time, reactant concentration, and the identity of the substituent of the polypyridyl ligand with the kinetics of the reactions and distribution of the products. The first step is the cleavage of [Ru(p-cymene)Cl2]2, followed by the coordination of R-phen via an associative mechanism and establishment of a direct correlation between the electron-donating or electron-withdrawing character of R and the reaction rates. The second step is the conversion of [Ru(R-phen)(p-cymene)Cl]Cl to cis-[Ru(R-phen)(dcbH2)Cl2], and the rate-determining step is the formation of the intermediate [Ru(R-phen)Cl2], which exhibits a low dependence on R. The last step is the substitution of Cl- by NCS-, and the N-bound isomer is the major product. The reaction temperature, time, and identity of R influence the relative distribution of the linkage isomers. The comprehension of each of these processes is a key factor to develop new strategies to optimize the one-pot synthetic route.

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent£¬ HPLC of Formula: C14H12N2O2, Which mentioned a new discovery about 92149-07-0

8-FLUOROPHTHALAZIN-1(2H)-ONE COMPOUNDS

8-Fluorophthalazin-1(2h)-one compounds of Formula I where one or two of X1, X2, and X3 are N, are provided, including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

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Reference£º
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Chemistry is traditionally divided into organic and inorganic chemistry. Safety of 4,7-Dimethoxy-1,10-phenanthroline. The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 92149-07-0

Photocatalytic alpha-Acylation of Ethers

Direct coupling of ethers and acyl halides was promoted by a binary catalytic system comprising an Ir-based photocatalyst and a Ni complex under blue-light irradiation. Photocatalysts with high triplet energy directed the catalysis, and the reaction likely proceeded by triplet-triplet energy transfer from the excited photocatalysts. Chlorine radicals generated from an excited Ni complex bearing a Ni-Cl bond would be responsible for generating alpha-oxy radicals leading to the alpha-acylated ethers.

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Reference£º
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Synthetic Route of 92149-07-0, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 92149-07-0, Name is 4,7-Dimethoxy-1,10-phenanthroline, molecular formula is C14H12N2O2. In a Article£¬once mentioned of 92149-07-0

Iron-Catalyzed Reductive Cyclization of o-Nitrostyrenes Using Phenylsilane as the Terminal Reductant

Using microscale high-throughput experimentation, an efficient, earth-abundant iron phenanthroline complex was discovered to catalyze the reductive cyclization of ortho-nitrostyrenes into indoles via nitrosoarene reactive intermediates. This method requires only 1 mol % of Fe(OAc)2 and 1 mol % of 4,7-(MeO)2phen and uses phenylsilane as a convenient terminal reductant. The scope and limitations of the method were illustrated with 21 examples, and an investigation into the kinetics of the reaction revealed first-order behavior in catalyst and silane and zero-order behavior with respect to nitrostyrene.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Synthetic Route of 92149-07-0, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 92149-07-0, in my other articles.

Reference£º
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.92149-07-0,4,7-Dimethoxy-1,10-phenanthroline,as a common compound, the synthetic route is as follows.

92149-07-0, Under an argon atmosphere, add anhydrous Fe(acac)3 (211.8mg, 0.6mmol) to a 50mL Schlenk flask, and dissolve it in 6mL of anhydrous ethanol at 60 C; Then, a solution of 4,7-dimethoxy-1,10-phenanthroline (144.0 mg, 0.6 mmol) in ethanol (4 mL) was added dropwise to the system. The reaction was carried out at 60 C for half an hour, and then returned to room temperature and stirred overnight. The filtrate was collected by filtration, concentrated, washed twice with cold ethanol, and dried under vacuum for 12 h to obtain a red-brown solid product 8 with a yield of 65%.

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Reference£º
Patent; Chinese Academy Of Sciences Tsingtao Biological Energies And Process Institute; Wang Qinggang; Wang Liang; Zhu Guangqian; Zhang Xianhui; Jing Chuyang; (29 pag.)CN110452272; (2019); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI