Category: 99970-84-0

99970-84-0,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.99970-84-0,[2,2′-Bipyridine]-4,4′-dicarbaldehyde,as a common compound, the synthetic route is as follows.

{RuCl(p-cymene)}2(50 mg, 0.08 mmol) and DiPy-G1-MEH (276 mg, 0.16 mmol) were dissolved in distilled DMF (25 mL). The reaction mixture was heated at 80 C. under nitrogen for 4 hours. Then, 2,2′-bipyridine-4,4′-dicarboxaldehyde (Dcbpy) (40 mg, 0.16 mmol) was added and refluxed at 150-160 degrees C. for another 4 hours under reduced light to avoid isomerization (2,2′-bipyridine-4,4′-dicarboxaldehyde was prepared according to the method described in N. Garelli et al, J. Org. Chem. 1992, 57, 3046). Subsequently, an excess of NH4NCS (310 mg, 4.1 mmol) was added to the mixture and heated at 150 C. for a further 4 h. The reaction mixture was cooled to room temperature and the solvent was removed by using a raotary evaporator under vacuum. Water (20 mL) was added to the flask and the insoluble solid was collected on a sintered glass crucible by suction filtration, and washed with distilled water. The crude complex was dissolved on a solution of tetrabutylammonium hydroxide (TBAH) in methanol (5 mL). the concentrated solution was charged onto a Sephadex LH-20 column and eluted with methanol. The main band was collected and concentrated. The required complex was isolated upon addition of 0.01M HNO3.

As the paragraph descriping shows that 99970-84-0 is playing an increasingly important role.

Reference£º
Patent; Isis Innovation Limited; Burn, Paul Leslie; An, Byeong-Kwan; Meredith, Paul; Deceglie, Michael Gardner; US8598350; (2013); B2;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

99970-84-0,99970-84-0, [2,2′-Bipyridine]-4,4′-dicarbaldehyde is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(5) Preparation of compound (6); To a compound (5) (0.13 g, 0.7 mmol) and KtOBu (0.2 g, 1.8 mmol), THF 20 mL was added, and the compound (3) (0.75 g, 1.8 mmol) was dissolved in 20 mL of THF and slowly added dropwise, and then the reaction mixture was agitated at 70 C for 12 hours. After the reaction, the solvent was removed and an organic layer was extracted with MC and separated by recrystallization.

99970-84-0 [2,2′-Bipyridine]-4,4′-dicarbaldehyde 4171663, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; DONGJIN SEMICHEM CO., LTD.; WO2009/82163; (2009); A2;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.99970-84-0,[2,2′-Bipyridine]-4,4′-dicarbaldehyde,as a common compound, the synthetic route is as follows.,99970-84-0

General procedure: 4-methyl-2,2?-bipyridine-4-formaldehyde (200mg, 1.01mmol) anddichloromethane (10 mL) were added into a 50 mL two-neck roundbottle flask under nitrogen. Then ethyl mercaptan (250 muL) and borontrifluoride ether solution (98%, 700 muL) were added into the flask.After the mixture was stirring at room temperature for one night, thesolvent were removed with rotary evaporator in vacuum. Then the saturatedsodium bicarbonate solution (50 mL) were added, the aqueoussolution was extracted with ethyl acetate five times. All organic layerswere collected and dried with anhydrous sodium sulfate, filtered andevaporated to dryness. The residue was purified by column chromatographyon silica gelwith dichloromethane as eluent to give the first bandas the product. The product is a colorless transparent oil (200mg) witha yield of 64.5%.

The synthetic route of 99970-84-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Xu, Jiru; Liu, Yonghua; Li, Mei-Jin; Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy; vol. 219; (2019); p. 141 – 146;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

99970-84-0, [2,2′-Bipyridine]-4,4′-dicarbaldehyde is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

99970-84-0, Dry potassium carbonate (1.7 g, 12.3 mmol) and 2.1 gtriethylphosphonoacetate were suspended in 10 cm3 of anhydrousTHF and stirred at room temperature for 15 min beforethe suspension was refluxed for 20 min. After cooling thesuspension to room temperature it was transferred into amicrowave vessel and 1.0 g (4.7 mmol) of (7) in 2 cm3 anhydrousTHF were added. The vessel was sealed and heated to110 C within 10 min using a maximum power of 1000MW.The reaction temperature then was maintained for 2 h afterwhich the vessel was allowed to cool down to room temperature.After cooling, 20 cm3 of a 10% potassium carbonatesolution was added. The mixture was extracted three timeswith ethyl acetate. The organic phase was dried over sodiumsulfate and the solvent was evaporated under reduced pressure.The remaining triethylphosphonoacetate was removedby distillation in vacuo. The crude product was purified bycolumn chromatography on silica gel using a diethyl ether:light petroleum (40-60) 1 : 1 mixture as the eluent. After thesolvent mixture was evaporated a white solid was obtainedwhich was recrystallized from ethanol/water by first dissolvingthe crude product in ethanol and then adding wateruntil the solution misted. For complete crystallization thesolution was placed in the refrigerator. Yield: 40% (0.66 g,1.88 mmol).IR (298 K) [cm-1]: 2980w, 2936vw, 1726vs, 1697vs,1584m, 1545w, 1458m, 1443m, 1377s, 1294s, 1263s, 1217vs,1063vs, 1011s, 991m, 930w, 880w, 860w, 843m, 791s, 770w,746m; MS (EI) m/z (%): 352 (10) [M+]; 323 (5) [M+-C2H5]; 308 (70) [M+-C2H5 – CH3]; 280 (100) [M+-C4H9O];261 (20) [M+-C4H11O2]; 233 (25) [M+-C6H15O2]; 208 (70)[M+-C8H18O2]; 1HNMR(CDCl3):delta ppm 1.36 (t, J = 7.07Hz, 6 H) 4.30 (q, J = 7.16 Hz, 4 H) 6.73 (s, 1 H) 6.77 (s, 1H) 7.41 (dd, J = 5.05, 1.77 Hz, 2 H) 7.73 (s, 1 H) 7.69 (s, 1H) 8.55-8.58 (m, 2 H) 8.73 (d, J = 5.05 Hz, 2 H); 13C-NMR(CDCl3):delta [ppm] = 14.2, 61.0, 119.3, 122.2, 123.1, 141.8,142.8, 150.0, 156.4, 166.1; M.p.: 139 C; elemental analysis:calc. (%) for C20H20N2O4: C 68.17, H 5.72, N 7.95; found:C 67.30, H 5.66, N 8.03.

As the paragraph descriping shows that 99970-84-0 is playing an increasingly important role.

Reference£º
Article; Heintz, Katharina; Goerls, Helmar; Imhof, Wolfgang; Journal of Chemical Sciences; vol. 130; 6; (2018);,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.99970-84-0,[2,2′-Bipyridine]-4,4′-dicarbaldehyde,as a common compound, the synthetic route is as follows.

99970-84-0, A mixture of 4,4′-diformyl-2,2′-bipyridine (234 mg,1.10 mmol) and 5-amino-1,10-phenanthroline (669 mg,3.43 mmol) in ethanol (50 mL) was heated to 80 C for12 h, giving a suspension. The reaction mixture was filtered hot, and the solid was washed with hot ethanol, affording the desired product as a yellow solid. Yield:486 mg (78 %). ESI-MS: m/z = 567.4 (M + H)+. 1HNMR (400 MHz, CDCl3): d = 7.68 (dd, J = 8.0, 4.8 Hz,2H), 7.74 (dd, J = 8.0, 4.4 Hz, 2H), 8.07 (dd, J = 5.2,1.2 Hz, 2H), 8.29 (dd, J = 2.8, 1.6 Hz, 2H), 8.31 (dd,J = 3.2, 1.6 Hz, 2H), 8.83 (dd, J = 8.4, 1.6 Hz, 2H), 8.88(s, 2H), 8.98 (d, J = 4.8 Hz, 2H), 9.07 (s, 2H), 9.19 (dd,J = 4.4, 2.0 Hz, 2H), 9.28 (dd, J = 4.4, 2.0 Hz, 2H). IR numax (KBr, cm-1): 3417 (br), 1628m, 1597s, 1554m,1505w, 1424m, 1383s, 1297w, 1206w, 1143w, 1062m,987w, 805w, 741s, 708w, 623w, 541w. Found: C 76.0, H3.8, N 19.7; Calcd for C36H22N8: C 76.3, H 3.9, N 19.8 %.

The synthetic route of 99970-84-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Cheng, Feixiang; Yu, Shiwen; Ren, Mingli; He, Chixian; Yin, Hongju; Transition Metal Chemistry; vol. 41; 3; (2016); p. 305 – 314;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

99970-84-0, [2,2′-Bipyridine]-4,4′-dicarbaldehyde is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

99970-84-0, 6-(2′-aminoethyl)-3,6,9-triaza-1(2,6)-pyridinacyclodecaphane (443.2 mg, 1.78 mmol) and 2,2′-bipyridine-4,4′-dicarbaldehyde(198 mg, 0.93 mmol) were dissolved in 40 mL of anhydrous ethanol and the mixture was stirred for 2 h at room temperature. NaBH4(550 mg, 14.5 mmol) was then added and the resulting solution stirred for 2 h at room temperature. The ethanol was removed under reduced pressure. The resulting residue was treated with H2O (10 mL) and extracted with CH2Cl2 (3 ¡Á 20mL). The organic phase was removed at reduced pressure, and the resulting residue was dissolved in ethanol and precipitated as the hydrochloride salt of L3 in 75% yield. mp: N 345 C. 1H NMR (300MHz, D2O): deltaH (ppm)=8.88 (d, J=5.5 Hz, 2H), 8.55 (s, 2H),7.94 (d, J=5.5 Hz, 2H), 7.92 (t, J=8 Hz, 2H), 7.42 (d, J=8 Hz, 4H), 4.60(s, 4H), 4.59 (s, 8H), 3.47 (t, J=8Hz, 4H), 3.26(t, J=5.3Hz, 8H), 3.13 (t,J = 8 Hz, 4H), 2.92 (t, J = 5.3 Hz, 8H). 13C NMR (75.43 MHz, D2O): deltaC(ppm) = 149.4, 148.9, 147.7, 146.1, 139.8, 127.0, 124.3, 122.2, 50.8,50.5, 50.0, 49.5, 45.9, 43.9. Calc for C38H54N12*8HCl*9H2O: C 40.3%, H7.1%,N 14.8%. Found: C 40.4%, H 7.3%, N 14.9%. MS (FAB)m/z 680 [MH]+.

99970-84-0 [2,2′-Bipyridine]-4,4′-dicarbaldehyde 4171663, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Gonzalez-Garcia, Jorge; Martinez-Camarena, Alvar; Verdejo, Begona; Clares, M. Paz; Soriano, Concepcion; Garcia-Espana, Enrique; Jimenez, Hermas R.; Domenech-Carbo, Antonio; Tejero, Roberto; Calvo, Enrique; Brianso-Llort, Laura; Serena, Carolina; Trefler, Sandra; Garcia-Espana, Antonio; Journal of Inorganic Biochemistry; vol. 163; (2016); p. 230 – 239;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

99970-84-0, [2,2′-Bipyridine]-4,4′-dicarbaldehyde is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a flame-dried round bottle flask with a magnetic stirring bar were addedbipyridine aldehyde (0.001 mmol) 2 and (DABCO) as catalyst (10 mol%)) in methanol(4mL), followed by the addition of activated alkenes 4. The resulting mixture was stirred atroom temperature for 12 hours, after completion of the reaction (Monitored by TLC),solvents were removed in vacuo and the residue was purified on neutral alumina using 70%ethyl acetate in petroleum ether to afford the corresponding novel Morita-Baylis-Hillmanadduct of bipyridine 5 in very good yield., 99970-84-0

The synthetic route of 99970-84-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Gouthaman, Siddan; Periyaraja, Somasundharam; Shanmugam, Ponnusamy; Tetrahedron Letters; vol. 56; 43; (2015); p. 5920 – 5923;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI