HPLC of Formula: 149554-29-0. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 6-(Piperazin-1-yl)nicotinonitrile, is researched, Molecular C10H12N4, CAS is 149554-29-0, about Decahydroisoquinoline derivatives as novel non-peptidic, potent and subtype-selective somatostatin sst3 receptor antagonists. Author is Troxler, Thomas; Hurth, Konstanze; Schuh, Karl-Heinrich; Schoeffter, Philippe; Langenegger, Daniel; Enz, Albert; Hoyer, Daniel.
Starting from non-peptidic sst1-selective somatostatin receptor antagonists, first compounds with mixed sst1/sst3 affinity were identified by directed structural modifications. Systematic optimization of these initial leads afforded novel, enantiomerically pure, highly potent and sst3-subtype selective somatostatin antagonists, e.g. I (R = piperonyl, 6-methoxypyridin-3-yl, 6-quinoxalinyl, etc.), based on a (4S,4aS,8aR)-decahydroisoquinoline-4-carboxylic acid core moiety. These compounds can efficiently be synthesized and show promising PK properties in rodents.
After consulting a lot of data, we found that this compound(149554-29-0)HPLC of Formula: 149554-29-0 can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI