Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 4-(p-Tolyl)-2,2:6,2-terpyridine, is researched, Molecular C22H17N3, CAS is 89972-77-0, about A new fluorescent probe for Zn2+ with red emission and its application in bioimaging.Safety of 4-(p-Tolyl)-2,2:6,2-terpyridine.
A new fluorescent probe, (E)-3-(3-(4-([2,2′:6′,2”-terpyridin]-4′-yl)phenyl)acryloyl)-7-(diethylamino)-2H-chromen-2-one (ZC-F4, I), composed of coumarin as the fluorophore and terpyridine as the receptor was designed and synthesized. This probe showed good selectivity and sensitivity towards Zn2+ even at the ppb level with significant variation of emission wavelength (more than 100 nm shifts) after combination with Zn2+. The emission color changed from green to red. A Job’s plot test suggested a 1:1 stoichiometry between ZC-F4 and Zn2+, and the theor. calculation based on d. functional theory has been carried out to gain an insight into the sensing mechanism. Furthermore, imaging of Zn2+ in cells was also performed to test its feasibility in biol. This fluorescence probe should be a promising candidate for applications in cell-imaging, environment protection, water treatment and safety inspection.
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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI