HPLC of Formula: 89972-77-0. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 4-(p-Tolyl)-2,2:6,2-terpyridine, is researched, Molecular C22H17N3, CAS is 89972-77-0, about DNA binding property, nuclease activity and cytotoxicity of Zn(II) complexes of terpyridine derivatives. Author is Jiang, Qin; Zhu, Jianhui; Zhang, Yangmiao; Xiao, Nan; Guo, Zijian.
Two zinc(II) terpyridine complexes Zn(atpy)2(PF6)2 (1) (atpy = 4′-p-N9′-adeninylmethylphenyl-2,2′:6,2″”-terpyridine) and Zn(ttpy)2(PF6)2 (2) (ttpy = 4′-p-tolyl-2,2′:6,2″”-terpyridine) were synthesized and characterized by elemental anal., 1H NMR and electrospray mass spectrometry. The structure of complex 2 was also determined by x-ray crystallog., which revealed a ZnN6 coordination in an octahedral geometry with two terpyridine acting as equatorial ligands. The CD data showed that complex 1 exhibited an ICD signal at ∼300 nm and induced more evident disturbances on DNA base stacking than complex 2, reflecting the impact of the adenine moiety on DNA binding modes. Complex 1 exhibited higher cleavage activity to supercoiled pUC 19 DNA than complex 2 under aerobic conditions, suggesting a promotional effect of adenine moiety in DNA nuclease ability. Both complexes demonstrated potent in vitro cytotoxicity against a series of human tumor cell lines such as human cervix carcinoma cell line (HeLa), human liver carcinoma cell line (HepG2), human galactophore carcinoma cell line (MCF-7) and human prostate carcinoma cell line (pc-3). The cytotoxicity is approx. 10 times more active than the anticancer drug cisplatin.
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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI