Electric Literature of C11H21BrO2. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 11-Bromoundecanoic acid, is researched, Molecular C11H21BrO2, CAS is 2834-05-1, about Modification of polyhydroxyalkanoates: Evaluation of the effectiveness of novel copper(II) catalysts in click chemistry. Author is Nkrumah-Agyeefi, Samuel; Pella, Bruce J.; Singh, Nirupama; Mukherjee, Anusree; Scholz, Carmen.
Copper(I) catalyzed azide-alkyne cycloadditions, click reactions, are an established synthetic tool to derivatize polymers. Only a few catalytic systems have been explored toward the derivatization of functionalized poly(3-hydroxyalkanoate)s, PHAs, using click reactions. Here, the performances of three Cu(II)-catalysts supported by tetradentate polypyridyl ligands, [Cu(L1)ClO4]ClO4, [Cu(L2)ClO4]ClO4 and [Cu(L3)ClO4]ClO4, were examined in click reactions on functionalized PHAs carrying either terminal azido or alkyne groups in the side chain and the results were compared to the traditional CuSO4·5H2O/Na ascorbate and the organo-soluble Cu(I) bromotris(triphenylphosphine)copper(I), CuBr(PPh3)3 catalysts. It was determined that the effectiveness of the catalytic systems depended on the mol. architecture of the polymer and the nature of the small mol. reactants to be clicked onto the PHA. Click reactions on PHAs with terminal azido groups were catalyzed with Cu(II)-catalysts, but not with CuBr(PPh3)3. For alkyne-containing polymers CuBr(PPH3)3 effected 65% conversion in contrast to Cu(II) catalysts that were ineffective. While no strong trend was found, differences in the effectiveness were related to dissimilarities in the accessibility of the alkyne moiety for the reactive Cu(I) species. Propargyl benzoate was most effectively clicked onto a azido PHA (100% conversion) when catalyzed by CuSO4·5H2O/Na ascorbate, however the click reaction with a similar reactant, propargyl acetate, was more effectively catalyzed by a Cu(II)-catalyst supported by a tetradentate polypyridyl ligand (44% conversion).
Different reactions of this compound(11-Bromoundecanoic acid)Electric Literature of C11H21BrO2 require different conditions, so the reaction conditions are very important.
Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI