The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 4-(p-Tolyl)-2,2:6,2-terpyridine(SMILESS: CC1=CC=C(C2=CC(C3=NC=CC=C3)=NC(C4=NC=CC=C4)=C2)C=C1,cas:89972-77-0) is researched.Name: Copper(I) tetra(acetonitrile) tetrafluoroborate. The article 《Furin Inhibition by Compounds of Copper and Zinc》 in relation to this compound, is published in Journal of Biological Chemistry. Let’s take a look at the latest research on this compound (cas:89972-77-0).
Furin, a human subtilisin-related proprotein convertase (SPC), is emerging as an important pharmaceutical target because it processes vital proteins of many aggressive pathogens. Furin inhibitors reported as yet are peptide derivatives and proteins, with the exception of andrographolides, which are natural compounds Here we report that the small and highly stable compounds M(chelate)Cl2 (M is copper or zinc) inhibit furin and Kex2, with Cu(TTP)Cl2 and Zn(TTP)Cl2 as the most efficient inhibitors. 4′-[P-tolyl]-2,2′:6′,2”-terpyridine (TTP) inhibitor is irreversible, competitive with substrate, and affected by substituents on the chelate. The free chelates are not inhibitors. Solvated Zn2+ is less potent than its complexes. This is true also for copper and Kex2. However, solvated Cu2+ (kon of 25,000±2,500 s-1) is more potent than Cu(TTP)Cl2 (kon = 140±13 s-1) and allows recovery of furin activity prior to a second inhibition phase. A mechanism that involves coordination to the catalytic histidine is proposed for all inhibitors. Target specificity is indicated by the fact that these metal chelate inhibitors are much less potent toward Kex2, the yeast homolog of furin. For example, kon with Zn(TTP)Cl2 is 120±20 s-1 for furin, but only 1.2±0.1 s-1 for Kex2.
This literature about this compound(89972-77-0)Computed Properties of C22H17N3has given us a lot of inspiration, and I hope that the research on this compound(4-(p-Tolyl)-2,2:6,2-terpyridine) can be further advanced. Maybe we can get more compounds in a similar way.
Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI