Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 5,6-Dihydro-2H-pyran-2-one, is researched, Molecular C5H6O2, CAS is 3393-45-1, about Asymmetric Synthesis of Chiral Bicyclo[2.2.1]hepta-2,5-diene Ligands through Rhodium-Catalyzed Asymmetric Arylative Bis-cyclization of a 1,6-Enyne.Application of 3393-45-1.
A series of novel chiral diene ligands (1R,4S)-L1, which were based on the bicyclo[2.2.1]heptadiene skeleton and were substituted with Me and an ester group at the bridgehead carbons, were synthesized through rhodium-catalyzed asym. arylative bis-cyclization of 1,6-enyne 1 as a key step. The rhodium catalyst with one of the (1R,4S)-L1 ligands was used for the asym. bis-cyclization of 1 giving bicyclic product (1S,4R)-2 of 99% ee, which is a synthetic precursor of (1S,4R)-L1 ligands.
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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI