Reference of 10045-25-7, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.10045-25-7, Name is 1,4,7,10-Tetraazacyclododecane tetrahydrochloride, molecular formula is C8H24Cl4N4. In a Article，once mentioned of 10045-25-7
The bicyclic tetraamine 1,4,7,10-tetraazabicyclo<5.5.3>pentadecane (L1) has been synthesized by the reaction of the ditosylate of cyclen <1,7-bis(p-toluenesulfonyl)-1,4,7,10-tetraazacyclododecane> with the ditosylate of 1,3-propanediol followed by removal of the tosyl groups.The amine isolated as the trihydrobromide, L1*3HBr, in an overall yield of 23percent (based upon cyclen).The structure of L1*2HBr*HClO4 has been solved by X-ray diffraction techniques at T=120 K; Mr=474.6, orthorhombic, Pnma, a=17.583(4), b=8.664(3), c=11.707(3) Angstroem, Z=4, Dx=1.77 g cm-3, MoKalpha=0.71073 Angstroem, mu=46.7 cm-1, F(000)=960.R(F)=0.0471 for 1815 reflections with I>2?(I) and wR(F2)=0.0803 for all 2761 unique reflections.The H3L13+ cation exhibits a mirror plane, the secondary nitrogen atoms and a carbon atom lying in the plane.The distance between the tertiary nitrogen atoms is 2.567(4) Angstroem, with one of the acidic hydrogen atoms situated midway between the two nitrogens.The distance between the two secondary nitrogen atoms is 5.194(7) Angstroem, giving rise to a rather elongated conformation of the cyclen ring.The free base L1 behaves as a proton sponge, being a stronger base than hydroxide in water.The concentration protonation constants were determined by potentiometric measurements, which combined with 13C NMR studies gave pK1>15, pK2=7.242(8), pK3=3.202(7) and pK4<-1. (1M NaBr, 25 deg C).The 13C NMR spectra of the mono- and triprotonated species correspond to a time-averaged C2v symmetry in solution. One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Reference of 10045-25-7, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 10045-25-7
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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI