A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, COA of Formula: C10Cl2Ti, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 1271-19-8, Name is Titanocenedichloride, molecular formula is C10Cl2Ti. In a Article, authors is Mijatovi, Sanja£¬once mentioned of 1271-19-8
Study of the anticancer properties of methyl- and phenyl-substituted carbon- and silicon-bridged ansa-titanocene complexes
The previously known complexes [Ti{(Me2CMe2C) (eta5-C5H4)2}Cl2] (1), [Ti{Me2C(eta5-C5H4) 2}Cl2] (2), [Ti {Me2Si(eta5-C 5H4)2}Cl2] (4), [Ti{MePhSi(eta 5-C5H4)2}Cl2] (5) and [Ti{MePhSi(eta5-C5Me4)2}Cl 2] (6) have been prepared following reported procedures. The novel complex [Ti{MePhC(eta5-C5H4) 2}Cl2] (3) has been prepared and characterized. The cytotoxic activity of 1-6 has been tested after 72 h on melanoma A375 and B16, prostate cancer DU145 and LNCaP and colon cancer HCT116, SW620 and CT26CL25 cell lines observing a high cytotoxic activity of complexes 1 and 6 compared to the reference compound ([Ti(eta5-C5H5) 2}Cl2]). 1 and 6 have also been tested against primary normal mouse keratinocytes and lung fibroblasts. While viability of both type of primary cells was significantly less affected by 1 in comparison to the reference compound [Ti(eta5-C5H5) 2Cl2], compound 6 was completely nontoxic for nonmalignant cells, indicating a potential selectivity of this compound towards cancer cell lines. In addition CFSE staining, cell cycle analysis, AnnexinV-FITC/PI staining, detection of caspase activity and mitochondrial potential showed that 1 and 6 were acting through inhibition of proliferation and subsequent induction of mitochondrial dependent apoptosis in colon cancer cell lines, HCT116 and SW620, which express low sensitivity to cisplatin. Compound 6 was found to be the leading drug in this group since it shows the fastest and most selective anticancer profile.
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 1271-19-8, help many people in the next few years.COA of Formula: C10Cl2Ti
Reference£º
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI