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L-proline diamides with an axially chiral binaphthylene backbone as efficient organocatalysts for direct asymmetric aldol reactions: The effect of acetic acid
A series of L-proline diamides derived from optically active 1,1?-binaphthyl-2,2?-diamines have been synthesized in good yields and their catalytic abilities as organocatalysts in direct asymmetric aldol reactions have been evaluated. Among these organo-catalysts, bis(prolinamides) exhibit higher catalytic abilities. The aldol reaction of arylaldehydes with acetone or cyclohexanone proceeds smoothly using the organocatalyst (10 mol%) in the presence of acetic acid (10 mol%) as an additive in toluene at -40C for 48-72 hours to give the corresponding aldol products in high yields (<90%) and with good to high enantioselectivities (<98%) and high anti-diastereoselectivities (<98:2). Georg Thieme Verlag Stuttgart. I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 18741-85-0, help many people in the next few years.Recommanded Product: (R)-[1,1′-Binaphthalene]-2,2′-diamine
Reference：
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI