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alpha-Oxo-beta-butyrolactam, N -containing pronucleophile in organocatalytic one-pot assembly of butyrolactam-fused indoloquinolizidines
The ambident reactivity of alpha-oxo-beta-butyrolactam has been explored in an organocatalytic one-pot Michael/Pictet-Spengler sequence. The synthetically interesting and medicinally important pentacyclic butyrolactam-fused indoloquinolizidines can be efficiently constructed in a highly stereocontrolled manner. Importantly, the chemistry described herein provides a general catalytic method for the enantioselective synthesis of butyrolactam-incorporated chemical entities.
One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Computed Properties of C20H27NOSi, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 943757-71-9
Reference£º
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI