With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.103946-54-9,4′-Methyl-[2,2′-bipyridine]-4-carboxylic acid,as a common compound, the synthetic route is as follows.
103946-54-9, Weigh the NH2-C4 dichloro bridge 1mmolAnd 2.2 mmol of 4-methyl 4′-carboxy-2,2′-bipyridine was added to the reaction flask, vacuumed, and protected with nitrogen.Reacted at 40 C for 10 h,After adding KPF630mmol reaction for 2h,Spin dry, extract with dichloromethane (3 ¡Á 150mL), take the organic phase, spin dry into silica gel powder column, separate and purify,The yield was 59%.
103946-54-9 4′-Methyl-[2,2′-bipyridine]-4-carboxylic acid 11127621, acatalyst-ligand compound, is more and more widely used in various fields.
Reference£º
Patent; Nanjing University of Posts and Telecommunications; Zhang Yin; Wei Huanjie; Zhang Taiwei; Zhao Qiang; Liu Shujuan; Huang Wei; (11 pag.)CN107880076; (2018); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI