With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.109073-77-0,[2,2′-Bipyridine]-4,4′-diyldimethanol,as a common compound, the synthetic route is as follows.
This reaction was performed under nitrogen atmosphere using freshly distilled,anhydrous solvents and reagents. Thionyl chloride (1.02 mL,14.0 mmol) was diluted with CH2Cl2 (15 mL) and the solution,cooled to 0 C, was added dropwise via syringe over 2 min to a cold(0 C) solution of lipoic acid (1.94 g, 9.36 mmol) in CH2Cl2 (25 mL).The solution was stirred at 0 C for 1 h, then the ice bath was removedand the solution was allowed to reach room temperature over 1 h. The solvents were removed in vacuo to leave lipoylchloride as a pale brown residue. This was dissolved in toluene (25 mL) and added dropwise over 30 min to a flask charged witha cold (0 C) solution of 3 (200 mg, 0.936 mmol) and Et3N (4.50 mL)in toluene (20 mL). The reaction was stirred overnight. Water(75 mL) was added, resulting in the formation of a brown precipitate.The mixture was filtered, the solid was discarded, and the organic layer was washed with water (250 mL) and dried over anhydrous Na2SO4. The solvent was removed in vacuo, to obtaina yellow crude product. This was purified by column chromatography using neutral alumina and hexane/ethyl acetate (2:1). After the less polar fraction (mostly lipoic acid) was separated, the eluentwas changed to hexane/ethyl acetate (1:4) to collect the fractions with the product. The solvent was removed in vacuo and theproduct was obtained as a yellow solid, 109073-77-0
As the paragraph descriping shows that 109073-77-0 is playing an increasingly important role.
Reference£º
Article; Kopecky, Andrew; Liu, Guangliang; Agushi, Ardian; Agrios, Alexander G.; Galoppini, Elena; Tetrahedron; vol. 70; 36; (2014); p. 6271 – 6275;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI