With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.130-95-0,Quinine,as a common compound, the synthetic route is as follows.
To a solution of quinine (78.2 mg, 0.2 mmol) in methanol (10 mL), a solution of ZnCl2 (27.2 mg, 0.2 mmol) in methanol (10 mL) was added. The mixture was stirred and heated at 50C for 2 h, and cooled to room temperature. The resulting solution was treated with aqueous HCl and filtered to remove staring materials. By slow evaporation of the filtrate at room temperature, white single crystals suitablefor X-ray diffraction were obtained after two weeks.The complex was identified as [(Quin)ZnCl3] (I). The yield was 78.8 mg (79.3%). IR (nu, cm-1): 3356 nu(OH), 3074 nu(CHar), 2971nu(CHaliph). For C20H25N2O2Cl3Zn anal. calcd., % C, 48.32 H, 5.07 N, 5.63Found, % C, 48.24 H, 5.02 N, 5.59, 130-95-0
The synthetic route of 130-95-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Gu; Jia; Zhang; Russian Journal of Coordination Chemistry; vol. 44; 1; (2018); p. 52 – 58; Koord. Khim.; vol. 44; 1; (2018); p. 52 – 58,7;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI