153-94-6, H-D-Trp-OH is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General procedure: To 4mL of ice-bath cooled methanol was added drop-wise 1mL of thionyl chloride in 5min under nitrogen, the resulting mixture was stirred for 0.5h and amine derivatives 3a-3f were added. The reaction mixture was stirred at room temperature overnight until complete disappearance of the materials indicated by TLC. The solvent and the surplus SOCl2 were removed in vacuum. The residue was dissolved in 20mL of methanol and evaporated under reduced pressure. The procedure was repeated for three times. Then 20mL of ether was added to the residue and evaporated in vacuum, which also took three times. Target compounds 4a-4f were obtained in 86%-95% yield and used without further purification for the following step., 153-94-6
As the paragraph descriping shows that 153-94-6 is playing an increasingly important role.
Reference£º
Article; Tang, Hong-Jin; Zhang, Xiao-Wei; Yang, Lin; Li, Wei; Li, Jia-Huang; Wang, Jin-Xin; Chen, Jun; European Journal of Medicinal Chemistry; vol. 124; (2016); p. 637 – 648;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI