4730-54-5,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4730-54-5,1,4,7-Triazacyclononane,as a common compound, the synthetic route is as follows.
NOTPA was prepared by the reaction of 1,4,7-triazacyclonoanane (TACN) (1 mmol, 0.10 g) and acrylic acid (3 mmol, 0.16 g) in acetone (30 mL), the reaction mixture was stirred at room temperature for 2 h to give a yellowish precipitate. The resulting precipitate was filtered and washed with diethyl ether and ethanol and dried in a vacuum oven to give a light yellow powder in 80 % yield (0.27 g). FTIR (KBr, Vmax, cm-1): 3411, 3231, 2935, 2845, 2350, 1751, 1654, 1402, 1240, 621; 1H NMR (400 MHz, DMSO, delta): 12.02 (s. 3H, OH). 3.62 (s, 6H, -CH2-CH2-C=0), 3.02 (s, 6H, N-CH2-CH2-C=O), 2.36 (t, 12H, N-CH2-CH2-N): 13C NMR (100 MHz, DMSO, delta) 172.80, 60.83, 52.12, 35.65 ppm; Anal. C15H27N306 (345.0): Calc: C, 52.17; H, 7.82; N, 12.17; found: C, 52.08; H, 7.70; N, 12.04% .
4730-54-5 1,4,7-Triazacyclononane 188318, acatalyst-ligand compound, is more and more widely used in various fields.
Reference£º
Article; Alshehri, Saad M.; Al-Farraj, Eida; Alhokbany, Norah; Ahamad, Tansir; Asian Journal of Chemistry; vol. 27; 6; (2015); p. 2209 – 2216;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI