With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.485-71-2,Cinchonidine,as a common compound, the synthetic route is as follows.
Preparation method of this embodiment Example 1 is the preparation method of compound 3a, which specifically includes the following steps: 0.5 mmol of cinconidine(1), 0.6 mmol of acetic acid (2a), 0.6 mmol of DCC, and 0.1 mmol of DMAP In a 50mL flask, then add dichloromethane (10mL) dried with calcium hydride, and then react at room temperature. The reaction process was followed by TLC to detect that the raw material (cinconidine) was complete. The reaction was completed. Urea gives the filtrate. The filtrate was then diluted with 50 mL of dichloromethane to obtain a dilution solution. The dilution solution was washed with 30 mL of 0.1 mol / L hydrochloric acid, 30 mL of a saturated sodium bicarbonate solution, and 30 mL of a saturated saline solution successively, and then dried over anhydrous sodium sulfate. . Then, the solvent (dichloromethane) was removed from the dried diluent under reduced pressure, and then separated by silica gel column chromatography (eluent was a mixed solution of ethyl acetate and petroleum ether with a volume ratio of 1: 1) to obtain compound 3a. The yield is 39%.
485-71-2 Cinchonidine 101744, acatalyst-ligand compound, is more and more widely used in various.
Reference£º
Patent; Henan University of Science and Technology; Che Zhiping; Tian Yuee; Chen Genqiang; Liu Shengming; Lin Xiaomin; Jiang Jia; Sun Di; Yang Jinming; (22 pag.)CN110642855; (2020); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI