With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.54258-41-2,1,10-Phenanthrolin-5-amine,as a common compound, the synthetic route is as follows.
General procedure: 4.2.1.4. Method D. A stirred solution of the 5-amino-1,10-phenanthroline (195 mg, 1 mmol), the monosaccharide (3 mmol) and ca. 4 mg of (NH4)2SO4 in 16 mL of MeOH was heated at 65 C for 24 or 48 h. During this time a pale yellow precipitate was accumulated. The reaction mixture was cooled and the solid obtained was separated by filtration and washed with MeOH (2 x 10 mL) and H2O (2 x 10 mL) to eliminate excess of sugar and possible traces of the starting amine and/or other by-products as well to remove the (NH4)2SO4 salt, followed by Et2O. This protocol provided pure N-(1,10-phenanthrolin-5-yl)-beta-glycopyranosyl amines 2a, 2c and 2d. For derivatives 2b and 2e the starting sugar could not be completely removed and a subsequent purification was required. The product was preadsorbed on silica gel and purified by flash chromatography. After drying in vacuum the purity of the products was checked by TLC, 1H NMR and analytical data. Derivatives 2a-e were obtained as monohydrates and exhibited poor solubility in water and organic solvents., 54258-41-2
54258-41-2 1,10-Phenanthrolin-5-amine 606970, acatalyst-ligand compound, is more and more widely used in various fields.
Reference£º
Article; Duskova, Katerina; Gude, Lourdes; Arias-Perez, Maria-Selma; Tetrahedron; vol. 70; 5; (2014); p. 1071 – 1076;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI