With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.54258-41-2,1,10-Phenanthrolin-5-amine,as a common compound, the synthetic route is as follows.
54258-41-2, General procedure: Both compounds were synthesized in the same way. A mixture ofthe appropriate aldehyde [thiophene-2,5-dicarbaldehyde (283 mg,2.02 mmol), furan-2,5-dicarbaldehyde (316 mg, 2.55 mmol)] and5-amino-1,10-phenanthroline [(1091 mg, 5.59 mmol) withthiophene-2,5-dicarbaldehyde, (1458 mg, 7.48 mmol) with furan-2,5-dicarbaldehyde] was refluxed in EtOH (50 mL) containing acatalytic amount of acetic acid for 12 h, giving a suspension. Thereaction mixture was filtered hot, and the solid was washed withEtOH to afford the desired product as a yellow solid.N,N0-[thiophene-2,5-diylbis(methan-1-yl-1-ylidene)]bis(1,10-phenanthroline-5-amine): Yield 926 mg, 92.8%. 1H NMR (400 MHz,CDCl3): d = 7.44 (s, 2H), 7.65 (dd, J = 8.0, 4.4 Hz, 2H), 7.69 (s, 2H),7.72 (dd, J = 8.0, 4.4 Hz, 2H), 8.27 (dd, J = 8.4, 1.6 Hz, 2H), 8.87(dd, J = 8.0, 1.6 Hz, 2H), 8.90 (s, 2H), 9.17 (dd, J = 4.4, 1.6 Hz, 2H),9.26 (dd, J = 4.4, 2.0 Hz, 2H). ESI-MS: m/z = 495.3 [M+H]+. IR mmax(KBr, cm1): 3423 (br), 1590 s, 1563m, 1503w, 1485w, 1423m,1384 s, 1239m, 1204w, 1143w, 1110w, 1060m, 973w, 874w,802w, 743m, 627w, 523w, 414w.
54258-41-2 1,10-Phenanthrolin-5-amine 606970, acatalyst-ligand compound, is more and more widely used in various fields.
Reference£º
Article; Cheng, Feixiang; He, Chixian; Yu, Shiwen; Yin, Hongju; Inorganica Chimica Acta; vol. 462; (2017); p. 43 – 49;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI