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An unprecedented cascade vinylogous Mukaiyama 1,6-MA/MA of 2-silyloxyfurans and azoalkenes was realized with a Cu(II)/tBu-Box complex. An array of fused butyrolactones containing multiple stereocenters was generally obtained in good yield (up to 90% yield) with exclusive diastereoselectivity (>20:1 dr) and excellent enantioselectivity (up to 99% ee). Carbon isotope effects measured by 13C NMR revealed a stepwise mechanism for this annulation process.
Because enzymes can increase reaction rates by enormous factors and tend to be very specific, Application In Synthesis of (4S,4’S)-2,2′-(Propane-2,2-diyl)bis(4-(tert-butyl)-4,5-dihydrooxazole), typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 131833-93-7
Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI