A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Application In Synthesis of N1-(3-Aminopropyl)-N1-methylpropane-1,3-diamine, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 105-83-9, Name is N1-(3-Aminopropyl)-N1-methylpropane-1,3-diamine, molecular formula is C7H19N3. In a Article, authors is Nagarajan, Muthukaman£¬once mentioned of 105-83-9
Synthesis and biological evaluation of bisindenoisoquinolines as topoisomerase I inhibitors
The indenoisoquinolines represent a class of non-camptothecin topoisomerase I (Topi) inhibitors that exert cytotoxicity by trapping the covalent complex formed between DNA and Topi during relaxation of DNA supercoils. As an ongoing evaluation of Top1 inhibition and anticancer activity, indenoisoquinolines were linked via their lactam side chains to provide polyamines end-capped with intercalating motifs. The resulting bisindenoisoquinolines were evaluated for cytotoxicity in the National Cancer Institute’s human cancer cell screen and for Top1 inhibition. Preliminary findings suggested that the 2-3-2 and 3-3-3 linkers, referring to the number of carbons between nitrogen atoms, were optimal for both potent Topi inhibition and cytotoxicity. Using optimized linkers, bisindenoisoquinolines were synthesized with nitro and methoxy substituents on the aromatic rings. The biological results for substituted compounds revealed a disagreement between the structure-activity relationships of monomeric indenoisoquinolines and bisindenoisoquinolines as Top1 inhibitors, but cytotoxicity was maintained for both series of compounds.
Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about is helpful to your research. Application In Synthesis of N1-(3-Aminopropyl)-N1-methylpropane-1,3-diamine
Reference£º
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI