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alpha,alpha-Diphenyl-L-prolinol derivatives with para-bromo substituants in either one or both of the phenyl rings are easily bound to crosslinked polystyrene beads containing phenylboronic acid residues by Suzuki couplings. By using extended reaction periods boronic acid residues that do not take part in the couplings are simply lost by hydrolysis. The polymer-supported (PS) alpha,alpha-diphenyl-L-prolinols were used to catalyse reductions of several prochiral ketones with borane in tetrahydrofuran at 22 C. The expected secondary alcohols were obtained in high chemical yields and ees were generally in the range 79-97 %. One PS catalyst was recycled 14 times without loss of stereochemical performance.
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Reference：
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI