Electric Literature of 153-94-6, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 153-94-6, Name is H-D-Trp-OH, molecular formula is C11H12N2O2. In a Article£¬once mentioned of 153-94-6
Design, synthesis, and evaluation of novel Akt1 inhibitors based on an indole scaffold
A new series of potential Akt1 inhibitors with indole scaffold were designed and synthesized. The antiproliferative activity against PC-3 cell line and enzyme inhibitory activity against Akt1 were evaluated. Among them, some compounds showed much more potent antiproliferative activity and stronger Akt1 inhibitory activity compared to the positive control of GSK690693. In particular, compound 19b exhibited the most potent inhibitory activity against Akt1 with inhibition rate of 70.3% at a concentration of 10?nm. Furthermore, compound 19b could dose dependently reduce the phosphorylation of the downstream GSK3beta protein in the PC-3 cell line and displayed fivefold higher antiproliferative activity against PC-3 cell line with IC50 value of 3.1?¡À?0.1?mum than positive control (15.5?¡À?0.4?mum). Herein, compound 19b may serve as a promising lead for further optimization and development of novel Akt1 inhibitors based on an indole scaffold.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Electric Literature of 153-94-6, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 153-94-6, in my other articles.
Reference£º
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI