Extracurricular laboratory:new discovery of Boc-Hyp-OL

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Chiral phosphinopyrrolidine compounds and their use for asymmetric synthesis of optically active compounds

New chiral phosphinopyrrolidine compounds of the general formula: STR1 wherein R1 is hydrogen or –COA1, –COOA2, –CONHA3, –SO2 A4 or –PO(A5)2, A1, A2, A3, A4 and A5 each represents independently alkyl or aryl, R2 is phenyl, di(lower-alkyl)aminophenyl, lower-alkoxyphenyl or 3,5-dimethyl-4-methoxyphenyl, and R3 is phenyl, lower-alkylphenyl, di(lower-alkyl)aminophenyl, lower-alkoxyphenyl or 3,5-dimethyl-4-methoxyphenyl, with the proviso that R2 and R3 may not simultaneously by phenyl, p-di(lower-alkyl)-aminophenyl or p-lower-alkoxyphenyl, as well as the use of these compounds as ligand for a metal complex catalyst for asymmetric synthesis of optically active compounds. The new chiral phosphinopyrrolidine compounds are useful ligands which attain both of high optical yield and high reaction efficiency in catalytic asymmetric reduction.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Quality Control of: Boc-Hyp-OL, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 61478-26-0, in my other articles.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI