Extracurricular laboratory:new discovery of Tris(2-pyridylmethyl)amine

Because enzymes can increase reaction rates by enormous factors and tend to be very specific, Quality Control of: Tris(2-pyridylmethyl)amine, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 16858-01-8

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent， Quality Control of: Tris(2-pyridylmethyl)amine, Which mentioned a new discovery about 16858-01-8

Three mononuclear cobalt(ii)-carboxylate complexes, [(TPA)CoII(benzilate)]+ (1), [(TPA)CoII(benzoate)]+ (2) and [(iso-BPMEN)CoII(benzoate)]+ (3), of N4 ligands (TPA = tris(2-pyridylmethyl)amine and iso-BPMEN = N1,N1-dimethyl-N2,N2-bis((pyridin-2-yl)methyl)ethane-1,2-diamine) were isolated to investigate their reactivity toward dioxygen. Monodentate (eta1) binding of the carboxylates to the metal centre favours the five-coordinate cobalt(ii) complexes (1-3) for dioxygen activation. Complex 1 slowly reacts with dioxygen to enable the oxidative decarboxylation of the coordinated alpha-hydroxy acid (benzilate). Prolonged exposure of the reaction solution of 2 to dioxygen results in the formation of [(DPA)CoIII(picolinate)(benzoate)]+ (4) and [CoIII(BPCA)2]+ (5) (DPA = di(2-picolyl)amine and HBPCA = bis(2-pyridylcarbonyl)amide), whereas only [(DPEA)CoIII(picolinate)(benzoate)]+ (6) (DPEA = N1,N1-dimethyl-N2-(pyridine-2-ylmethyl)-ethane-1,2-diamine) is isolated from the final oxidised solution of 3. The modified ligand DPA (or DPEA) is formed via the oxidative C-N bond cleavage of the supporting ligands. Further oxidation of the -CH2- moiety to -C(O)- takes place in the transformation of DPA to HBPCA on the cobalt(ii) centre. Labelling experiments with 18O2 confirm the incorporation of oxygen atoms from molecular oxygen into the oxidised products. Mixed labelling studies with 16O2 and H2O18 strongly support the involvement of water in the C-N bond cleavage pathway. A comparison of the dioxygen reactivity of the cobalt complexes (1-3) with those of several other five-coordinate mononuclear complexes [(TPA)CoII(X)]+/2+ (X = Cl, CH3CN, acetate, benzoylformate, salicylate and phenylpyruvate) establishes the role of the carboxylate co-ligands in the activation of dioxygen and subsequent oxidative cleavage of the supporting ligands by a metal-oxygen oxidant.

Because enzymes can increase reaction rates by enormous factors and tend to be very specific, Quality Control of: Tris(2-pyridylmethyl)amine, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 16858-01-8

Reference：
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI