80875-98-5, Name is H-Oic-OH, molecular formula is C9H15NO2, Formula: C9H15NO2, belongs to catalyst-ligand compound, is a common compound. In a patnet, author is Wang, Yidong, once mentioned the new application about 80875-98-5.
Iron-catalyzed alpha-C-H functionalization of pi-bonds: cross-dehydrogenative coupling and mechanistic insights
The deprotonation of propargylic C-H bonds for subsequent functionalization typically requires stoichiometric metal alkyl or amide reagents. In addition to the undesirable generation of stoichiometric metallic waste, these conditions limit the functional group compatibility and versatility of this functionalization strategy and often result in regioisomeric mixtures. In this article, we report the use of dicarbonyl cyclopentadienyliron(ii) complexes for the generation of propargylic anion equivalents toward the direct electrophilic functionalization of propargylic C-H bonds under mild, catalytic conditions. This technology was applied to the direct conversion of C-H bonds to C-C bonds for the synthesis of several functionalized scaffolds through a one-pot cross dehydrogenative coupling reaction with tetrahydroisoquinoline and related privileged heterocyclic scaffolds. A series of NMR studies and deuterium-labelling experiments indicated that the deprotonation of the propargylic C-H bond was the rate-determining step when a Cp*Fe(CO)(2)-based catalyst system was employed.
We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 80875-98-5. The above is the message from the blog manager. Formula: C9H15NO2.
Reference:
Metal catalyst and ligand design,
,Ligand Template Strategies for Catalyst Encapsulation – NCBI