Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Recommanded Product: 2,2′-Bipyridine, 366-18-7, Name is 2,2′-Bipyridine, molecular formula is C10H8N2, belongs to catalyst-ligand compound. In a document, author is Sato, Yasuhiro, introduce the new discover.
New Bifunctional Bis(azairidacycle) with Axial Chirality via Double Cyclometalation of 2,2 ‘-Bis(aminomethyl)-1,1 ‘-binaphthyl
As a candidate for bifunctional asymmetric catalysts containing a half-sandwich C-N chelating Ir(III) framework (azairidacycle), a dinuclear Ir complex with an axially chiral linkage is newly designed. An expedient synthesis of chiral 2,2 ‘-bis(aminomethyl)-1,1 ‘-binaphthyl (1) from 1,1-bi-2-naphthol (BINOL) was accomplished by a three-step process involving nickel-catalyzed cyanation and subsequent reduction with Raney-Ni and KBH4. The reaction of (S)-1 with an equimolar amount of [IrCl2Cp*](2) (Cp* = eta(5)-C-5(CH3)(5)) in the presence of sodium acetate in acetonitrile at 80 degrees C gave a diastereomeric mixture of new dinuclear dichloridodiiridium complexes (5) through the double C-H bond cleavage, as confirmed by H-1 NMR spectroscopy. A loss of the central chirality on the Ir centers of 5 was demonstrated by treatment with KOC(CH3)(3) to generate the corresponding 16e amidoiridium complex 6. The following hydrogen transfer from 2-propanol to 6 provided diastereomers of hydrido(amine)iridium retaining the bis(azairidacycle) architecture. The dinuclear chlorido(amine)iridium 5 can serve as a catalyst precursor for the asymmetric transfer hydrogenation of acetophenone with a substrate to a catalyst ratio of 200 in the presence of KOC(CH3)(3) in 2-propanol, leading to (S)-1-phenylethanol with up to an enantiomeric excess (ee) of 67%.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 366-18-7. Recommanded Product: 2,2′-Bipyridine.
Reference:
Metal catalyst and ligand design,
,Ligand Template Strategies for Catalyst Encapsulation – NCBI