Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 89972-77-0, is researched, SMILESS is CC1=CC=C(C2=CC(C3=NC=CC=C3)=NC(C4=NC=CC=C4)=C2)C=C1, Molecular C22H17N3Journal, Article, Research Support, Non-U.S. Gov’t, Journal of Inorganic Biochemistry called Improving nuclease activity of copper(II)-terpyridine complex through solubilizing and charge effects of glycine, Author is Zhou, Wen; Wang, Xiaoyong; Hu, Ming; Guo, Zijian, the main research direction is glycine copper terpyridine complex solubility artificial DNase crystal structure.Formula: C22H17N3.
Copper complexes are potential metallonucleases that may find application in biotechnol. and mol. biol. In this study, a ternary copper-terpyridine complex [Cu(ttpy)(Gly)(NO3)](NO3)·H2O (1) (ttpy = 4′-p-tolyl-2,2′:6,2”-terpyridine) is synthesized and characterized by X-ray crystallog. and ESI-MS as an artificial nuclease. Glycine is introduced into the complex to enhance the water-solubility and electrostatic affinity for the nucleic acid target. The interaction between complex 1 and DNA has been studied by spectroscopy and gel electrophoresis, using a structural analog [Cu(ttpy)(NO3)2] (2) as the reference Complex 1 demonstrates an increased DNA binding ability and oxidative cleavage activity towards supercoiled pBR322 DNA as compared with complex 2. The enhanced water-solubility and pos. charge of complex 1 may facilitate its access to DNA and formation of hydrogen bonds with the sugar-phosphate backbone. The results indicate that carefully positioned auxiliary groups in a copper complex can significantly affect the substrate binding or activation ability and consequently the nuclease efficiency of the complex.
《Improving nuclease activity of copper(II)-terpyridine complex through solubilizing and charge effects of glycine》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(4-(p-Tolyl)-2,2:6,2-terpyridine)Formula: C22H17N3.
Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI