Related Products of 1271-19-8, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.1271-19-8, Name is Titanocenedichloride, molecular formula is C10Cl2Ti. In a article£¬once mentioned of 1271-19-8
Cuprate addition to a 6-substituted pentafulvene – Preparation of sec-alkyl-substituted titanocene dichlorides and their biological activity
The copper-catalysed (10 mol-% CuBr¡¤SMe2, CuCN¡¤LiCl or CuI/PPh3) addition of RMgBr to the pentafulvene 1-(cyclopenta-2,4-dien-1-ylidenemethyl)-2-methoxybenzene allows the formation of cyclopentadienyl derivatives with alpha-CHR(2-MeOPh) sidechains (R = Me, Et, nBu, iBu, allyl, Ph) without H- transfer. The deprotonation of these sec-alkyl-substituted cyclopentadienyls followed by the addition of TiCl 4 allows the isolation of TiCl2{eta5-C 5H4CHR(2-OMePh)} as rac/meso mixtures that show activity against human colon, breast and pancreatic cell lines (GI50 2.3-42.4 muM). The direct addition of alkyllithium and Grignard reagents with beta-hydrogen atoms to fulvenes has been dogged with the problem of competing hydride transfer. Copper catalysis overcomes this and allows access to titanocene dichlorides with high anticancer activity. Copyright
We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 1271-19-8, and how the biochemistry of the body works.Related Products of 1271-19-8
Reference£º
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI