Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 131833-93-7, molcular formula is C17H30N2O2, introducing its new discovery. Recommanded Product: (4S,4’S)-2,2′-(Propane-2,2-diyl)bis(4-(tert-butyl)-4,5-dihydrooxazole)
Desymmetrization by Asymmetric Copper-Catalyzed Intramolecular C-H Insertion Reactions of alpha-Diazo-beta-oxosulfones
Effective desymmetrization in copper-catalyzed intramolecular C-H insertion reactions of alpha-diazo-beta-oxosulfones in the formation of fused thiopyran dioxides is described for the first time. The use of a copper-bis(oxazoline)-NaBARF catalyst complex system leads to formation of the major thiopyran dioxide stereoisomer with up to 98:2 dr and up to 98% ee. The effect of varying the bis(oxazoline) ligand, copper salt, and site of C-H insertion on both diastereo- and enantioselectivities of these intramolecular C-H insertion reactions has been investigated. Similarly, desymmetrization in the formation of a fused cyclopentanone proceeds with up to 64% ee. These results represent the highest enantioselectivity reported to date in a copper-mediated desymmetrization through C-H insertion.
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Reference£º
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI