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Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent， Safety of (1S,2S)-(-)-1,2-Diphenylethylenediamine, Which mentioned a new discovery about 29841-69-8

The highly enantioselective NHC-catalyzed [3+2] annulation reaction with alpha,beta-alkynals and alpha-ketoesters has been developed. A new mode of cooperative catalysis involving the combination of a chiral Bronsted acid and a C1-symmetric biaryl saturated-imidazolium precatalyst was required to generate the desired gamma-crotonolactones in high yields and levels of enantioselectivity.

Because enzymes can increase reaction rates by enormous factors and tend to be very specific, Safety of (1S,2S)-(-)-1,2-Diphenylethylenediamine, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 29841-69-8

Reference：
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI