Safety of (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one, is researched, Molecular C5H8O3, CAS is 32780-06-6, about Studies directed towards the asymmetric total synthesis of antileukemic lignan lactones. Synthesis of optically pure key intermediate and its utility. Author is Tomioka, Kiyoshi; Koga, Kenji.
The preparation of the β-piperonyl-γ-lactone I (RR1 = O), the key intermediate in the synthesis of lignan lactones, from the chiral γ-lactone synthon II is reported. II was converted in 60% yield in three steps to the triol III, which gave 98% of the hemiacetal I (R = H, R1 = OH) on oxidation with NaIO4. Collins oxidation of I (R = H, R1 = OH) gave 89% optically pure I (RR1 = O) which was converted into several optically pure natural lignan lactones, e.g. (-)-hinokinin (IV).
Although many compounds look similar to this compound(32780-06-6)Safety of (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one, numerous studies have shown that this compound(SMILES:O=C1O[C@H](CO)CC1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.
Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI