A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 72-19-5, Name is H-Thr-OH, molecular formula is C4H9NO3. In an article, author is Xu, You-Wei,once mentioned of 72-19-5, Recommanded Product: H-Thr-OH.
Enantioselective Copper-Catalyzed [3+3] Cycloaddition of Tertiary Propargylic Esters with 1H-Pyrazol-5(4H)-ones toward Optically Active Spirooxindoles
A copper-catalyzed enantioselective [3 + 3] cycloaddition of 3-ethynyl-2-oxoindolin-3-yl acetates with 1H-pyrazol-5(4H)-ones for the construction of optically active spirooxindoles bearing a spiro all-carbon quaternary stereocenter has been realized. With a combination of Cu(OTf)(2) and chiral tridentate ketimine P,N,N-ligand as the catalyst, the reaction displayed broad substrate scopes, good yields, and high enantioselectivities. This represents the first catalytic asymmetric propargylic cycloaddition with tertiary propargylic esters as the bis-electrophiles for access to chiral spirocyclic frameworks.
Interested yet? Keep reading other articles of 72-19-5, you can contact me at any time and look forward to more communication. Recommanded Product: H-Thr-OH.
Reference:
Metal catalyst and ligand design,
,Ligand Template Strategies for Catalyst Encapsulation – NCBI