Let¡¯s face it, organic chemistry can seem difficult to learn, Category: catalyst-ligand, Especially from a beginner¡¯s point of view. Like 147-85-3, Name is H-Pro-OH, molecular formula is CH2F3NO2S, belongs to benzoxazole compound. In a document, author is Gilbert, Sophie H., introducing its new discovery.
Rhodium catalysts derived from a fluorinated phanephos ligand are highly active catalysts for direct asymmetric reductive amination of secondary amines
An asymmetric hydrogenation of enamines is efficiently catalysed by rhodium complexed with a fluorinated version of the planar chiral paracyclophane-diphosphine ligand, Phanephos. This catalyst was shown to be very active, with examples operating at just 0.1 mol% of catalyst. This catalyst was then successfully adapted to Direct Asymmetric Reductive Amination, leading to the formation of several tertiary amines with moderate ee, if activated ketone/amine partners are used. (C) 2020 Elsevier Ltd. All rights reserved.
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Reference:
Metal catalyst and ligand design,
,Ligand Template Strategies for Catalyst Encapsulation – NCBI