Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent， HPLC of Formula: C12H7BrN2, Which mentioned a new discovery about 66127-01-3
Two novel porphyrin-core systems were prepared by Sonogashira cross-coupling of the terminal alkyne groups of meso-tetra(4-ethynylphenyl)porphyrin-Zn(ii) (P-1) with halogenated Ru(ii)- or Ir(iii)-phenanthroline complexes. The resulting compounds (P-Ru and P-Ir) were spectroscopically characterised and their photophysical properties were investigated (lambdaem 625, 665 nm; tauT 339.6 mus (P-Ru) and lambdaem 530, 612, 664 nm; tauT 396.6 mus (P-Ir)). Nanosecond time-resolved transient absorption studies were used to explore the 3MLCT nature of the triplet excited states, and the singlet oxygen quantum yields were determined (PhiDelta 44.8 (P-Ru), 33.2 (P-Ir)%). The subcellular uptake of P-Ru and P-Ir and their application as photosensitisers (PS) in photodynamic therapy (PDT) were explored due to their solution photophysics and absence of dark toxicity. Upon irradiation (lambdaexc = 620-630 nm; 10 min; 33 J cm-2), both P-Ru and P-Ir killed 90% of SKBR-3 cells at 1 muM. Notably P-Ru induced a 77% decrease in cell viability at only 0.25 muM.
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 66127-01-3, help many people in the next few years.HPLC of Formula: C12H7BrN2
Reference：
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI