Lory, Pedro M. J.; Estrella-Jimenez, Maria E.; Shashack, Matthew J.; Lokesh, Ganesh L.; Natarajan, Amarnath; Gilbertson, Scott R. published the article 《Synthesis and screening of 3-substituted thioxanthen-9-one-10,10-dioxides》. Keywords: thioxanthenone dioxide carbamoyl amino preparation BRCT hepatitis C inhibitor.They researched the compound: 6-(Piperazin-1-yl)nicotinonitrile( cas:149554-29-0 ).Quality Control of 6-(Piperazin-1-yl)nicotinonitrile. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:149554-29-0) here.
Methods appropriate for the parallel synthesis of libraries based on the thioxanthen-9-one 10,10-dioxide scaffold are reported. The novel compounds were synthesized from previously reported 3-chlorothioxanthen-9-one-10,10-dioxide and com. available 3-carboxythioxanthen-9-one 10,10-dioxide. The library members were screened for activity in a fluorescence polarization assay for inhibitors of BRCT domains of breast cancer gene 1 and in cell-based secreted alk. phosphatase reported replicon system for activity against hepatitis C virus.
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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI