With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.153-94-6,H-D-Trp-OH,as a common compound, the synthetic route is as follows.
General procedure: 5-Bromothiophene-2-sulfonylchloride (1g, 4.43 mmol) was added to a solution of the appropriate non-natural commercial amino acid (4.43 mmol) in H2O (4.43 mL) and dioxane (13.3 mL) containing Et3N (1.24 mL, 8.86 mmol). The mixture was stirred at room temperature overnight, the dioxane was evaporated and the residue was treated with EtOAc and washed with HCl 1 N and brine. Organic layers were then collected, dried over Na2SO4, and evaporated in vacuo.
153-94-6, As the paragraph descriping shows that 153-94-6 is playing an increasingly important role.
Reference£º
Article; Nuti, Elisa; Casalini, Francesca; Santamaria, Salvatore; Gabelloni, Pamela; Bendinelli, Sara; Da Pozzo, Eleonora; Costa, Barbara; Marinelli, Luciana; La Pietra, Valeria; Novellino, Ettore; Margarida Bernardo; Fridman, Rafael; Da Settimo, Federico; Martini, Claudia; Rossello, Armando; European Journal of Medicinal Chemistry; vol. 46; 7; (2011); p. 2617 – 2629;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI